A total synthesis of resibufogenin (12b) and bufalin (1a) has been summarized. Digitoxigenin (2a) was employed as relay and converted to 14-dehydrobufalin acetate (11). The latter substance was transformed to resibufogenin (12b) and bufalin (1a). The synthesis represents a new approach to the bufadienolides and constitutes the first synthetic route from a cardenolide to a bufadienolide.
ASJC Scopus subject areas
- Organic Chemistry