Abstract
A total synthesis of resibufogenin (12b) and bufalin (1a) has been summarized. Digitoxigenin (2a) was employed as relay and converted to 14-dehydrobufalin acetate (11). The latter substance was transformed to resibufogenin (12b) and bufalin (1a). The synthesis represents a new approach to the bufadienolides and constitutes the first synthetic route from a cardenolide to a bufadienolide.
Original language | English (US) |
---|---|
Pages (from-to) | 2895-2898 |
Number of pages | 4 |
Journal | Journal of Organic Chemistry |
Volume | 35 |
Issue number | 9 |
DOIs | |
State | Published - Jan 1 1970 |
ASJC Scopus subject areas
- Organic Chemistry