Brain MR radiomics to differentiate cognitive disorders

Alzheimer's Disease Neuroimaging Initiative

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Objective: Subtle and gradual changes occur in the brain years before cognitive impairment due to age-related neurodegenerative disorders. The authors examined the utility of hippocampal texture analysis and volumetric features extracted from brain magnetic resonance (MR) data to differentiate between three cognitive groups (cognitively normal individuals, individuals with mild cognitive impairment, and individuals with Alzheimer’s disease) and neuropsychological scores on the Clinical Dementia Rating (CDR) scale. Methods: Data from 173 uni que pati ents with 3-T T1-weighted MR images from the Alzheimer’s Disease Neuroimaging Initiative database were analyzed. A variety of texture and volumetric features were extracted from bilateral hippocampal regions and were used to perform binary classification of cognitive groups and CDR scores. The authors used diagonal quadratic discriminant analysis in a leave-one-out cross-validation scheme. Sensitivity, specificity, and area under the receiver operating characteristic curve were used to assess the performance of models. Results: The results show promise for hippocampal texture analysis to distinguish between no impairment and early stages of impairment. Volumetric features were more successful at differentiating between no impairment and advanced stages of impairment. Conclusions: MR radiomics may be a promising tool to classify various cognitive groups.

Original languageEnglish (US)
Pages (from-to)210-219
Number of pages10
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number3
StatePublished - Jul 2019
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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