Biofilms and the plasmid maintenance question

Mudassar Imran, Donald Jones, Hal Smith

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Can a conjugative plasmid encoding enhanced biofilm forming abilities for its bacterial host facilitate the persistence of the plasmid in a bacterial population despite conferring diminished growth rate and segregative plasmid loss on its bearers? We construct a mathematical model in a chemostat and in a plug flow environment to answer this question. Explicit conditions for an affirmative answer are derived. Numerical simulations support the conclusion.

Original languageEnglish (US)
Pages (from-to)183-204
Number of pages22
JournalMathematical Biosciences
Issue number2
StatePublished - Feb 1 2005


  • Bacterial wall growth
  • Biofilm
  • Chemostat
  • Conjugation
  • Model
  • Plasmid
  • Plug flow
  • Segregation

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences
  • Applied Mathematics


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