TY - JOUR
T1 - Associations of accelerometer-measured sedentary time and physical activity with prospectively assessed cardiometabolic risk factors
T2 - The CARDIA study
AU - Whitaker, Kara M.
AU - Gabriel, Kelley Pettee
AU - Buman, Matthew
AU - Pereira, Mark A.
AU - Jacobs, David R.
AU - Reis, Jared P.
AU - Gibbs, Bethany Barone
AU - Carnethon, Mercedes R.
AU - Staudenmayer, John
AU - Sidney, Stephen
AU - Sternfeld, Barbara
N1 - Publisher Copyright:
© 2019 The Authors.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background-—Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity; however, existing studies are limited by cross-sectional study designs. Methods and Results-—Participants were 1922 adults from the CARDIA (Coronary Artery Risk Development in Young Adults) study. Linear regression examined the associations of sedentary, light-intensity physical activity, and moderate-to-vigorous intensity physical activity at year 20 (2005–2006) with waist circumference, blood pressure, glucose, insulin, triglycerides, high-density lipoprotein cholesterol, and a composite risk score at year 30 (2015–2016). Models then examined change in activity with change in cardiometabolic risk over the same 10-year period. Replacing 30 min/day of sedentary time with 30 min/day of light-intensity physical activity at year 20 was associated with a lower composite risk score ( 0.01 SD [95% CI, 0.02, 0.00]) at year 30, characterized by lower waist circumference (0.15 cm [95% CI, 0.27, 0.02]), insulin (0.20 lU/mL [95% CI, 0.35, 0.04]), and higher high-density lipoprotein cholesterol (0.20 mg/dL [95% CI, 0.00, 0.40]; all P<0.05). An increase of 30 min/day in MVPA from year 20 to year 30, when replacing an equivalent increase in sedentary time, was associated with a decrease in the composite risk score ( 0.08 [95% CI, 0.13, 0.04]) over the same 10 years, characterized by a decrease in waist circumference (1.52 cm [95% CI, 2.21, 0.84]), insulin ( 1.13 lU/mL [95% CI, 1.95, 0.31]), triglycerides ( 6.92 mg/dL [95% CI, 11.69, 2.15]), and an increase in high-density lipoprotein cholesterol (1.59 mg/dL [95% CI, 0.45, 2.73]; all P<0.05). Conclusions-—Replacement of sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity is associated with improved cardiometabolic health 10 years later.
AB - Background-—Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity; however, existing studies are limited by cross-sectional study designs. Methods and Results-—Participants were 1922 adults from the CARDIA (Coronary Artery Risk Development in Young Adults) study. Linear regression examined the associations of sedentary, light-intensity physical activity, and moderate-to-vigorous intensity physical activity at year 20 (2005–2006) with waist circumference, blood pressure, glucose, insulin, triglycerides, high-density lipoprotein cholesterol, and a composite risk score at year 30 (2015–2016). Models then examined change in activity with change in cardiometabolic risk over the same 10-year period. Replacing 30 min/day of sedentary time with 30 min/day of light-intensity physical activity at year 20 was associated with a lower composite risk score ( 0.01 SD [95% CI, 0.02, 0.00]) at year 30, characterized by lower waist circumference (0.15 cm [95% CI, 0.27, 0.02]), insulin (0.20 lU/mL [95% CI, 0.35, 0.04]), and higher high-density lipoprotein cholesterol (0.20 mg/dL [95% CI, 0.00, 0.40]; all P<0.05). An increase of 30 min/day in MVPA from year 20 to year 30, when replacing an equivalent increase in sedentary time, was associated with a decrease in the composite risk score ( 0.08 [95% CI, 0.13, 0.04]) over the same 10 years, characterized by a decrease in waist circumference (1.52 cm [95% CI, 2.21, 0.84]), insulin ( 1.13 lU/mL [95% CI, 1.95, 0.31]), triglycerides ( 6.92 mg/dL [95% CI, 11.69, 2.15]), and an increase in high-density lipoprotein cholesterol (1.59 mg/dL [95% CI, 0.45, 2.73]; all P<0.05). Conclusions-—Replacement of sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity is associated with improved cardiometabolic health 10 years later.
KW - Cardiometabolic risk
KW - Epidemiology
KW - Isotemporal substitution
KW - Physical activity
KW - Sedentary time
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U2 - 10.1161/JAHA.118.010212
DO - 10.1161/JAHA.118.010212
M3 - Article
C2 - 30616480
AN - SCOPUS:85059929168
SN - 2047-9980
VL - 8
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 1
M1 - e010212
ER -