Association of Markers of Inflammation with Sleep and Physical Activity Among People Living with HIV or AIDS

Michael D. Wirth, Jason R. Jaggers, Wesley D. Dudgeon, James R. Hébert, Shawn Youngstedt, Steven N. Blair, Gregory A. Hand

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


This study examined associations of sleep and minutes spent in moderate-vigorous physical activity (MVPA) with C-reactive protein (CRP) and interleukin (IL)-6 among persons living with HIV. Cross-sectional analyses (n = 45) focused on associations of inflammatory outcomes (i.e., CRP and IL-6) with actigraph-derived sleep duration, latency, and efficiency; sleep onset; wake time; and wake-after-sleep-onset; as well as MVPA. Least square means for CRP and IL-6 by levels of sleep and MVPA were computed from general linear models. Individuals below the median of sleep duration, above the median for sleep onset, and below the median of MVPA minutes had higher CRP or IL-6 levels. Generally, individuals with both low MVPA and poor sleep characteristics had higher inflammation levels than those with more MVPA and worse sleep. Understanding the combined impact of multiple lifestyle/behavioral factors on inflammation could inform intervention strategies to reduce inflammation and therefore, chronic disease risk.

Original languageEnglish (US)
Pages (from-to)1098-1107
Number of pages10
JournalAIDS and Behavior
Issue number6
StatePublished - Jun 22 2015


  • Acquired immunodeficiency syndrome
  • Exercise
  • HIV
  • Inflammation
  • Sleep

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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