Association of early experience with neurodegeneration in aged primates

David A. Merrill; Eliezer Masliah; Jeffery A. Roberts; Heather McKay; Jeffery H. Kordower; Elliott J. Mufson; Mark H. Tuszynski

doi:10.1016/j.neurobiolaging.2009.01.014

Association of early experience with neurodegeneration in aged primates

David A. Merrill, Eliezer Masliah, Jeffery A. Roberts, Heather McKay, Jeffery H. Kordower, Elliott J. Mufson, Mark H. Tuszynski

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Environment influences brain development, neurogenesis and, possibly, vulnerability to neurodegenerative disease. We retrospectively examined the brains of aged rhesus monkeys reared during early life in either small cages or larger, " standard-sized" cages; all monkeys were subsequently maintained in standard-sized cages during adulthood. Aged monkeys reared in smaller cages exhibited significantly greater β-amyloid plaque deposition in the neocortex and a significant reduction in synaptophysin immunolabeling in cortical regions compared to aged monkeys reared in standard-sized cages (p< 0.001 and p< 0.05, respectively). These findings suggest that early environment may influence brain structure and vulnerability to neurodegenerative changes in late life.

Original language	English (US)
Pages (from-to)	151-156
Number of pages	6
Journal	Neurobiology of Aging
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/j.neurobiolaging.2009.01.014
State	Published - Jan 2011
Externally published	Yes

Keywords

Aging
Environment
Neocortex
Neurodegeneration
Rhesus monkey
Synapse density
Synaptophysin
β-Amyloid

ASJC Scopus subject areas

Neuroscience(all)
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2009.01.014

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title = "Association of early experience with neurodegeneration in aged primates",

abstract = "Environment influences brain development, neurogenesis and, possibly, vulnerability to neurodegenerative disease. We retrospectively examined the brains of aged rhesus monkeys reared during early life in either small cages or larger, {"} standard-sized{"} cages; all monkeys were subsequently maintained in standard-sized cages during adulthood. Aged monkeys reared in smaller cages exhibited significantly greater β-amyloid plaque deposition in the neocortex and a significant reduction in synaptophysin immunolabeling in cortical regions compared to aged monkeys reared in standard-sized cages (p< 0.001 and p< 0.05, respectively). These findings suggest that early environment may influence brain structure and vulnerability to neurodegenerative changes in late life.",

keywords = "Aging, Environment, Neocortex, Neurodegeneration, Rhesus monkey, Synapse density, Synaptophysin, β-Amyloid",

author = "Merrill, {David A.} and Eliezer Masliah and Roberts, {Jeffery A.} and Heather McKay and Kordower, {Jeffery H.} and Mufson, {Elliott J.} and Tuszynski, {Mark H.}",

note = "Funding Information: This work was supported by the NIH (AG10435) and the California Regional Primate Research Center Base Grant (RR00169), and the Shiley Family Foundation. ",

year = "2011",

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language = "English (US)",

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AU - Merrill, David A.

AU - Masliah, Eliezer

AU - Roberts, Jeffery A.

AU - McKay, Heather

AU - Kordower, Jeffery H.

AU - Mufson, Elliott J.

AU - Tuszynski, Mark H.

N1 - Funding Information: This work was supported by the NIH (AG10435) and the California Regional Primate Research Center Base Grant (RR00169), and the Shiley Family Foundation.

PY - 2011/1

Y1 - 2011/1

N2 - Environment influences brain development, neurogenesis and, possibly, vulnerability to neurodegenerative disease. We retrospectively examined the brains of aged rhesus monkeys reared during early life in either small cages or larger, " standard-sized" cages; all monkeys were subsequently maintained in standard-sized cages during adulthood. Aged monkeys reared in smaller cages exhibited significantly greater β-amyloid plaque deposition in the neocortex and a significant reduction in synaptophysin immunolabeling in cortical regions compared to aged monkeys reared in standard-sized cages (p< 0.001 and p< 0.05, respectively). These findings suggest that early environment may influence brain structure and vulnerability to neurodegenerative changes in late life.

AB - Environment influences brain development, neurogenesis and, possibly, vulnerability to neurodegenerative disease. We retrospectively examined the brains of aged rhesus monkeys reared during early life in either small cages or larger, " standard-sized" cages; all monkeys were subsequently maintained in standard-sized cages during adulthood. Aged monkeys reared in smaller cages exhibited significantly greater β-amyloid plaque deposition in the neocortex and a significant reduction in synaptophysin immunolabeling in cortical regions compared to aged monkeys reared in standard-sized cages (p< 0.001 and p< 0.05, respectively). These findings suggest that early environment may influence brain structure and vulnerability to neurodegenerative changes in late life.

KW - Aging

KW - Environment

KW - Neocortex

KW - Neurodegeneration

KW - Rhesus monkey

KW - Synapse density

KW - Synaptophysin

KW - β-Amyloid

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JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 1

ER -

Association of early experience with neurodegeneration in aged primates

Abstract

Keywords

ASJC Scopus subject areas

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