TY - JOUR
T1 - Association of C-reactive protein with mild cognitive impairment
AU - Roberts, Rosebud O.
AU - Geda, Yonas E.
AU - Knopman, David S.
AU - Boeve, Bradley F.
AU - Christianson, Teresa J.H.
AU - Pankratz, V. Shane
AU - Kullo, Iftikhar J.
AU - Tangalos, Eric G.
AU - Ivnik, Robert J.
AU - Petersen, Ronald C.
N1 - Funding Information:
This study was supported by the National Institute on Aging (grants U01-AG06786, K01-AG028573, and P50-AG16574), the National Institute of Mental Health (grant K01-MH68351), and the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program.
PY - 2009/9
Y1 - 2009/9
N2 - Background: Inflammation is proposed to play a role in the development of Alzheimer's disease, and may also be involved in the pathogenesis of mild cognitive impairment (MCI). This study examined the association of inflammatory markers in serum or plasma with prevalent MCI and MCI subtypes in a population-based sample. Methods: Olmsted County, MN, residents aged 70-89 years on October 1, 2004, were evaluated using the Clinical Dementia Rating Scale, a neurological evaluation, and neuropsychological testing. Information ascertained for each participant was reviewed by an expert panel of neuropsychologists, physicians, and nurses, and a diagnosis of normal cognition, MCI, or dementia was made by consensus. C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis alpha (TNFα), and adiponectin were measured at baseline. Results: Among 313 subjects with MCI and 1570 cognitively normal subjects, a CRP level in the upper quartile (>3.3 mg/L) was significantly associated with MCI (odds ratio [OR], 1.42; 95% confidence interval [CI], 1.00-2.01) and with nonamnestic MCI (OR, 2.05; 95% CI, 1.12-3.78) after adjusting for age, sex, and years of education. However, there was no association with amnestic MCI (OR, 1.21; 95% CI, 0.81-1.82). No association was observed with the other inflammatory markers. Conclusions: Plasma CRP is associated with prevalent MCI and with nonamnestic MCI in elderly, nondemented persons in a population-based setting. These findings suggest the involvement of inflammation in the pathogenesis of MCI.
AB - Background: Inflammation is proposed to play a role in the development of Alzheimer's disease, and may also be involved in the pathogenesis of mild cognitive impairment (MCI). This study examined the association of inflammatory markers in serum or plasma with prevalent MCI and MCI subtypes in a population-based sample. Methods: Olmsted County, MN, residents aged 70-89 years on October 1, 2004, were evaluated using the Clinical Dementia Rating Scale, a neurological evaluation, and neuropsychological testing. Information ascertained for each participant was reviewed by an expert panel of neuropsychologists, physicians, and nurses, and a diagnosis of normal cognition, MCI, or dementia was made by consensus. C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis alpha (TNFα), and adiponectin were measured at baseline. Results: Among 313 subjects with MCI and 1570 cognitively normal subjects, a CRP level in the upper quartile (>3.3 mg/L) was significantly associated with MCI (odds ratio [OR], 1.42; 95% confidence interval [CI], 1.00-2.01) and with nonamnestic MCI (OR, 2.05; 95% CI, 1.12-3.78) after adjusting for age, sex, and years of education. However, there was no association with amnestic MCI (OR, 1.21; 95% CI, 0.81-1.82). No association was observed with the other inflammatory markers. Conclusions: Plasma CRP is associated with prevalent MCI and with nonamnestic MCI in elderly, nondemented persons in a population-based setting. These findings suggest the involvement of inflammation in the pathogenesis of MCI.
KW - Adiponectin
KW - C-reactive protein
KW - Cross-sectional
KW - Cytokines
KW - Inflammation
KW - Interleukin-6
KW - Mild cognitive impairment
KW - Population-based
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U2 - 10.1016/j.jalz.2009.01.025
DO - 10.1016/j.jalz.2009.01.025
M3 - Article
C2 - 19751919
AN - SCOPUS:69949135434
SN - 1552-5260
VL - 5
SP - 398
EP - 405
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 5
ER -