Application of embryonic and adult zebrafish for nanotoxicity assessment

Jiangxin Wang, Xiaoshan Zhu, Yongsheng Chen, Yung Chang

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations


As an emerging model for toxicological studies, zebrafish has been explored for nanotoxicity assessment. In addition to endpoint examination of embryo/fish mortality and/or developmental disorders, molecular analyses of differential gene expression have also been employed to evaluate toxic effects associated with the exposure to nanomaterials. Here, we describe zebrafish-based assays, including both embryo and adult, for evaluation of nanotoxicity caused by metal oxide nanoparticles (NPs), in particular, zinc oxide (ZnO) and titanium oxide (TiO<inf>2</inf>) nanoparticles.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages13
ISBN (Print)9781627030014
StatePublished - 2012

Publication series

NameMethods in Molecular Biology
ISSN (Print)10643745


  • Acute
  • Chronic toxicity
  • Microarray
  • Nanoparticles
  • Nanotoxicology
  • Zebrafish embryos

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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