Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris

George Pettit; John C. Knight; Delbert L. Herald; Robin Pettit; Fiona Hogan; Venugopal J R V Mukku; John S. Hamblin; Michael J. Dodson; Jean Chapuis

doi:10.1021/np800603u

Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris

George Pettit, John C. Knight, Delbert L. Herald, Robin Pettit, Fiona Hogan, Venugopal J R V Mukku, John S. Hamblin, Michael J. Dodson, Jean Chapuis

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Two new cyclodepsipeptides designated bacillistatins 1 (1)and2(2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI ₅₀'s of 10 ^-4-10 ^-5 μg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.

Original language	English (US)
Pages (from-to)	366-371
Number of pages	6
Journal	Journal of Natural Products
Volume	72
Issue number	3
DOIs	https://doi.org/10.1021/np800603u
State	Published - Mar 27 2009

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np800603u

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title = "Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris",

abstract = "Two new cyclodepsipeptides designated bacillistatins 1 (1)and2(2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI 50's of 10 -4-10 -5 μg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.",

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year = "2009",

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AU - Pettit, George

AU - Knight, John C.

AU - Herald, Delbert L.

AU - Pettit, Robin

AU - Hogan, Fiona

AU - Mukku, Venugopal J R V

AU - Hamblin, John S.

AU - Dodson, Michael J.

AU - Chapuis, Jean

PY - 2009/3/27

Y1 - 2009/3/27

N2 - Two new cyclodepsipeptides designated bacillistatins 1 (1)and2(2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI 50's of 10 -4-10 -5 μg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.

AB - Two new cyclodepsipeptides designated bacillistatins 1 (1)and2(2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI 50's of 10 -4-10 -5 μg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.

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Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris

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CCDC 715993: Experimental Crystal Structure Determination

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Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris

Abstract

ASJC Scopus subject areas

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CCDC 715993: Experimental Crystal Structure Determination

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