An investigation of the Phillippine Ampelocissus sp. roots for cancer cell growth inhibitory components led to the isolation of a new acetogenin characterized as 22-epicalamistrin (1) employing primarily 2D NMR and high-resolution mass spectral analysis. Two other antineoplastic constituents proved to be the known acetogenin uvaribonin (2) and chalcone 3. Constituents 1-3 were all found to show significant cancer cell growth inhibitory activity against a panel of human cancer cell lines.
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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Pettit, G. R. (Creator), Mukku, V. J. R. V. (Creator), Cragg, G. (Creator), Herald, D. L. (Creator), Knight, J. C. (Creator), Herald, C. L. (Creator), Chapuis, J. (Creator) & Pettit, G. R. (Creator), The Cambridge Structural Database, 2008