Antineoplastic agents 385. The isolation and structure of a scalarane-type sesterterpene from the Indian Ocean porifera Hyrtios erecta

George Pettit; Zbigniew Cichacz; Rui Tan; Delbert L. Herald; Noeleen Melody; Michael S. Hoard; Dennis L. Doubek; John N A Hooper

doi:10.1135/cccc19981671

Antineoplastic agents 385. The isolation and structure of a scalarane-type sesterterpene from the Indian Ocean porifera Hyrtios erecta

George Pettit, Zbigniew Cichacz, Rui Tan, Delbert L. Herald, Noeleen Melody, Michael S. Hoard, Dennis L. Doubek, John N A Hooper

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Bioassay-guided separation techniques were employed to isolate (3.3-10^-7% yield) a new murine P388 lymphocytic leukemia cell line inhibitor (ED₅₀ 2.9 μg/ml) 12-O-deacetyl-19-deoxyscalarin from extracts of the Republic of Maldives marine sponge Hyrtios erecta. The structure was deduced using high field 2D NMR and high resolution mass spectral methods and confirmed by X-ray crystal structure determination.

Original language	English (US)
Pages (from-to)	1671-1677
Number of pages	7
Journal	Collection of Czechoslovak Chemical Communications
Volume	63
Issue number	10
DOIs	https://doi.org/10.1135/cccc19981671
State	Published - Oct 1998

Keywords

Crystal structure
Marine sponge
NMR spectroscopy
Natural products
Scalarolides
Sesterterpenes
Terpenes
X-ray diffraction

ASJC Scopus subject areas

General Chemistry

Access to Document

10.1135/cccc19981671

Cite this

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title = "Antineoplastic agents 385. The isolation and structure of a scalarane-type sesterterpene from the Indian Ocean porifera Hyrtios erecta",

abstract = "Bioassay-guided separation techniques were employed to isolate (3.3-10-7% yield) a new murine P388 lymphocytic leukemia cell line inhibitor (ED50 2.9 μg/ml) 12-O-deacetyl-19-deoxyscalarin from extracts of the Republic of Maldives marine sponge Hyrtios erecta. The structure was deduced using high field 2D NMR and high resolution mass spectral methods and confirmed by X-ray crystal structure determination.",

keywords = "Crystal structure, Marine sponge, NMR spectroscopy, Natural products, Scalarolides, Sesterterpenes, Terpenes, X-ray diffraction",

author = "George Pettit and Zbigniew Cichacz and Rui Tan and Herald, {Delbert L.} and Noeleen Melody and Hoard, {Michael S.} and Doubek, {Dennis L.} and Hooper, {John N A}",

year = "1998",

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doi = "10.1135/cccc19981671",

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volume = "63",

pages = "1671--1677",

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T1 - Antineoplastic agents 385. The isolation and structure of a scalarane-type sesterterpene from the Indian Ocean porifera Hyrtios erecta

AU - Pettit, George

AU - Cichacz, Zbigniew

AU - Tan, Rui

AU - Herald, Delbert L.

AU - Melody, Noeleen

AU - Hoard, Michael S.

AU - Doubek, Dennis L.

AU - Hooper, John N A

PY - 1998/10

Y1 - 1998/10

N2 - Bioassay-guided separation techniques were employed to isolate (3.3-10-7% yield) a new murine P388 lymphocytic leukemia cell line inhibitor (ED50 2.9 μg/ml) 12-O-deacetyl-19-deoxyscalarin from extracts of the Republic of Maldives marine sponge Hyrtios erecta. The structure was deduced using high field 2D NMR and high resolution mass spectral methods and confirmed by X-ray crystal structure determination.

AB - Bioassay-guided separation techniques were employed to isolate (3.3-10-7% yield) a new murine P388 lymphocytic leukemia cell line inhibitor (ED50 2.9 μg/ml) 12-O-deacetyl-19-deoxyscalarin from extracts of the Republic of Maldives marine sponge Hyrtios erecta. The structure was deduced using high field 2D NMR and high resolution mass spectral methods and confirmed by X-ray crystal structure determination.

KW - Crystal structure

KW - Marine sponge

KW - NMR spectroscopy

KW - Natural products

KW - Scalarolides

KW - Sesterterpenes

KW - Terpenes

KW - X-ray diffraction

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DO - 10.1135/cccc19981671

M3 - Article

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JO - Collection of Czechoslovak Chemical Communications

JF - Collection of Czechoslovak Chemical Communications

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Antineoplastic agents 385. The isolation and structure of a scalarane-type sesterterpene from the Indian Ocean porifera Hyrtios erecta

Abstract

Keywords

ASJC Scopus subject areas

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CCDC 136231: Experimental Crystal Structure Determination

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Antineoplastic agents 385. The isolation and structure of a scalarane-type sesterterpene from the Indian Ocean porifera Hyrtios erecta

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Datasets

CCDC 136231: Experimental Crystal Structure Determination

Cite this