Abstract
Bioassay-guided separation of cancer cell growth inhibitory fractions derived from the sea hare Dolabella auricularia obtained in Papua New Guinea led to isolation (1.51 x 10-7 % yield) of the new thiazole-containing peptide, dolastatin 18 (4). Structural determination was completed by employment of results from high-field (500 MHz) 2-D NMR experiments and tandem MS/MS mass spectral sequence analyses. Dolastatin 18 (4) was found to inhibit a selection of cancer cell lines among which GI50 0.39 μg/mL was found for the non-small cell lung cancer NCI-H460.
Original language | English (US) |
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Pages (from-to) | 827-832 |
Number of pages | 6 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 7 |
Issue number | 7 |
DOIs | |
State | Published - Apr 8 1997 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry