Antineoplastic agents, 162.1 zephyranthes candida

George Pettit; Gordon M. Cragg; Sheo Bux Singh; James A. Duke; Dennis L. Doubek

doi:10.1021/np50067a026

Antineoplastic agents, 162.¹ zephyranthes candida

George Pettit, Gordon M. Cragg, Sheo Bux Singh, James A. Duke, Dennis L. Doubek

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

The Chinese medicinal plant Zephyranthes candida was found to contain a cytostatic constituent. Separation of a n-BuOH extract directed by results of a bioassay employing the P-388 lymphocytic leukemia led to trans-dihydronarciclasine [2] as the principal cytostatic agent with ED₅₀ 3.2 X 10^-3 μ-g/ml.

Original language	English (US)
Pages (from-to)	176-178
Number of pages	3
Journal	Journal of Natural Products
Volume	53
Issue number	1
DOIs	https://doi.org/10.1021/np50067a026
State	Published - 1990

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np50067a026

Cite this

@article{f3918ef5b48a4216ad1f2788c3089ded,

title = "Antineoplastic agents, 162.1 zephyranthes candida",

abstract = "The Chinese medicinal plant Zephyranthes candida was found to contain a cytostatic constituent. Separation of a n-BuOH extract directed by results of a bioassay employing the P-388 lymphocytic leukemia led to trans-dihydronarciclasine [2] as the principal cytostatic agent with ED50 3.2 X 10-3 μ-g/ml.",

author = "George Pettit and Cragg, {Gordon M.} and Singh, {Sheo Bux} and Duke, {James A.} and Doubek, {Dennis L.}",

year = "1990",

doi = "10.1021/np50067a026",

language = "English (US)",

volume = "53",

pages = "176--178",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "1",

}

TY - JOUR

T1 - Antineoplastic agents, 162.1 zephyranthes candida

AU - Pettit, George

AU - Cragg, Gordon M.

AU - Singh, Sheo Bux

AU - Duke, James A.

AU - Doubek, Dennis L.

PY - 1990

Y1 - 1990

N2 - The Chinese medicinal plant Zephyranthes candida was found to contain a cytostatic constituent. Separation of a n-BuOH extract directed by results of a bioassay employing the P-388 lymphocytic leukemia led to trans-dihydronarciclasine [2] as the principal cytostatic agent with ED50 3.2 X 10-3 μ-g/ml.

AB - The Chinese medicinal plant Zephyranthes candida was found to contain a cytostatic constituent. Separation of a n-BuOH extract directed by results of a bioassay employing the P-388 lymphocytic leukemia led to trans-dihydronarciclasine [2] as the principal cytostatic agent with ED50 3.2 X 10-3 μ-g/ml.

UR - http://www.scopus.com/inward/record.url?scp=0025312060&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025312060&partnerID=8YFLogxK

U2 - 10.1021/np50067a026

DO - 10.1021/np50067a026

M3 - Article

C2 - 2348199

AN - SCOPUS:0025312060

SN - 0163-3864

VL - 53

SP - 176

EP - 178

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 1

ER -

Antineoplastic agents, 162.¹ zephyranthes candida

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this