Antineoplastic Agents, 116. An Evaluation of the Marine Ascidian Aplidium Californicum

George Pettit, John E. Leet, Cherry L. Herald, Yoshiaki Kamano, Dennis L. Doubek

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The antineoplastic constituents of the marine ascidian Aplidium californicum were found to be bryostatins 4 and 5. Bioassay-directed isolation procedures using the National Cancer Institute's P-388 lymphocytic leukemia system led to the bryostatins. The probable symbiotic relationship between A. californicum and the bryozoan Bugula neritina was discussed.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
JournalJournal of Natural Products
Issue number2
StatePublished - 1986

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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