Antineoplastic agents, 103. the isolation and structure of hypoestestatins 1 and 2 from the east african hypoestes verticillaris1

George Pettit; Animesh Goswami; Gordon M. Cragg; Jean M. Schmidt; Ji Chun Zou

doi:10.1021/np50036a001

Antineoplastic agents, 103. the isolation and structure of hypoestestatins 1 and 2 from the east african hypoestes verticillaris¹

George Pettit, Animesh Goswami, Gordon M. Cragg, Jean M. Schmidt, Ji Chun Zou

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

The East African shrub Hypoëstes verticillaris representing a heretofore chemically unexplored Acanthaceae genus has been found to contain two new cell growth inhibitory (murine P-388 lymphocytic leukemia) phenanthroindolizidine alkaloids termed hypoestestatin 1 (la) and hypoestestatin 2 (lb). Both substances were found to markedly inhibit growth of the murine P-388 cell line (ED₅₀= 10^-5 μ/ml). The structures of hypoestestatins 1 and 2 were assigned primarily on the basis of results from extensive spectral studies.

Original language	English (US)
Pages (from-to)	913-919
Number of pages	7
Journal	Journal of Natural Products
Volume	47
Issue number	6
DOIs	https://doi.org/10.1021/np50036a001
State	Published - Jan 1984

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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AU - Schmidt, Jean M.

AU - Zou, Ji Chun

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Antineoplastic agents, 103. the isolation and structure of hypoestestatins 1 and 2 from the east african hypoestes verticillaris¹

Abstract

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