TY - JOUR
T1 - Animal models of age- and disease-related cognitive decline
T2 - Perspectives on the models and therapeutic strategies
AU - Kordower, Jeffrey H.
AU - Gash, Don M.
N1 - Funding Information:
J.H.K. is supported by a grant from the American Health Assistance Foundation. We would like to thank Dr. R. T. Bartus for comments on an earlier draft of this manuscript.
PY - 1988
Y1 - 1988
N2 - The relative value of animals with memory impairments, due either to experimental lesions or aging processes, is dependent upon the specific hypothesis being tested. The experimental approaches described in the preceding reviews are valuable for basic studies on learning and memory in the mammalian brain. However, because of important differences between available model systems and human disease states, such as Alzheimer's disease, their use at present may be insufficient for understanding and developing treatment strategies for human cognitive dysfunctions. In this commentary, different aspects of animal models of memory dysfunction will be discussed relative to their ability to assess the structural and functional consequences of central nervous system (CNS) repair.
AB - The relative value of animals with memory impairments, due either to experimental lesions or aging processes, is dependent upon the specific hypothesis being tested. The experimental approaches described in the preceding reviews are valuable for basic studies on learning and memory in the mammalian brain. However, because of important differences between available model systems and human disease states, such as Alzheimer's disease, their use at present may be insufficient for understanding and developing treatment strategies for human cognitive dysfunctions. In this commentary, different aspects of animal models of memory dysfunction will be discussed relative to their ability to assess the structural and functional consequences of central nervous system (CNS) repair.
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U2 - 10.1016/S0197-4580(88)80132-5
DO - 10.1016/S0197-4580(88)80132-5
M3 - Article
C2 - 3211266
AN - SCOPUS:0024159691
SN - 0197-4580
VL - 9
SP - 685
EP - 689
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - C
ER -