Abstract
Field-effect biosensors based on nanowires enjoy considerable popularity due to their high sensitivity and direct electrical readout [1]. However, crucial issues such as the influence of the biomolecules on the charge-carrier transport or the binding of molecules to the surface have not been described satisfactorily yet in a quantitative manner. In order to analyze these effects, we present simulation results based on a 3D macroscopic transport model coupled with Monte-Carlo simulations for the bio-functionalized surface layer. Excellent agreement with measurement data has been found, while detailed study of the influence of the most prominent biomolecules, namely double-stranded DNA and single-stranded DNA, on the current through the semiconductor transducer has been carried out.
Original language | English (US) |
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Title of host publication | Procedia Engineering |
Pages | 407-410 |
Number of pages | 4 |
Volume | 25 |
DOIs | |
State | Published - 2011 |
Externally published | Yes |
Event | 25th Eurosensors Conference - Athens, Greece Duration: Sep 4 2011 → Sep 7 2011 |
Other
Other | 25th Eurosensors Conference |
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Country/Territory | Greece |
City | Athens |
Period | 9/4/11 → 9/7/11 |
Keywords
- Field-effect biosensors
- Field-effect DNA sensors
- Sensor simulation
- Silicon nanowire
ASJC Scopus subject areas
- General Engineering