Analogues of bleomycin: Synthesis of conformationally rigid methylvalerates

Michael J. Rishel, Sidney M. Hecht

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


(equation presented) Several conformationally rigid analogues of the methylvalerate subunit contained within the linker domain of the antitumor antibiotic bleomycin have been prepared. These compounds have been protected in a fashion suitable for the solid-phase synthesis of bleomycin. Bleomycin congeners containing these analogues should facilitate a more detailed understanding of the nature of the conformational bend that the methylvalerate moiety is thought to impart to the natural product.

Original languageEnglish (US)
Pages (from-to)2867-2869
Number of pages3
JournalOrganic Letters
Issue number18
StatePublished - Sep 6 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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