An evolutionary explanation for the presence of cancer nonstem cells in neoplasms

Kathleen Sprouffske, C Athena Aktipis, Jerald P. Radich, Martin Carroll, Aurora M. Nedelcu, Carlo Maley

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Contrary to conventional views that assume all cells in a neoplasm can propagate the tumor, the cancer stem cell hypothesis posits that only a fraction of the cells (the cancer stem cells) can act as tumor-propagating cells, while most of the tumor is composed of cells with limited replication potential. Here, we offer an evolutionary approach to this controversy. We used several evolutionary, computational models to investigate cancer cell dynamics and conditions consistent with the stem cell hypothesis. Our models predict that if selection acts at the cell level, neoplasms should be primarily comprised of cancer stem cells, in contrast to experimental data indicating that neoplasms contain large fractions of cancer nonstem cells. We explore several solutions explaining the paradoxical existence of cancer nonstem cells in neoplasms, including the possibility that selection acts at the level of multicellular proliferative units.

Original languageEnglish (US)
Pages (from-to)92-101
Number of pages10
JournalEvolutionary Applications
Issue number1
StatePublished - Jan 2013

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • General Agricultural and Biological Sciences


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