Alzheimer's disease: Aβ, tau and synaptic dysfunction

Frank M. LaFerla, Salvatore Oddo

Research output: Contribution to journalReview articlepeer-review

375 Scopus citations


Alzheimer's disease is a progressive neurodegenerative disorder that is characterized by two hallmark lesions: extracellular amyloid plaques and neurofibrillary tangles. The role that these lesions have in the pathogenesis of AD has proven difficult to unravel, in part because of unanticipated challenges of reproducing both pathologic hallmarks in transgenic mice. Recent advances in recapitulating both plaques and tangles in the brains of transgenic mice are leading to novel insights into their role in the degenerative process, including their impact on synaptic activity and plasticity. Transgenic mice that harbor both neuropathological lesions are also facilitating the elucidation of the relationship of these proteinaceous aggregates to one another and providing a crucial in vivo system for developing and evaluating therapies.

Original languageEnglish (US)
Pages (from-to)170-176
Number of pages7
JournalTrends in Molecular Medicine
Issue number4
StatePublished - Apr 2005
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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