Alteration of the selectivity of DNA cleavage by a deglycobleomycin analogue containing a trithiazole moiety

Medicine & Life Sciences

• deglycobleomycin 100%
• DNA Cleavage 59%
• Bleomycin 50%
• Superhelical DNA 26%
• DNA 24%
• Metals 22%
• Tentagel resin 19%
• bleomycetin 15%
• Solid-Phase Synthesis Techniques 14%
• Thiazoles 13%
• RNA Cleavage 13%
• indium-bleomycin 11%
• Ions 7%
• RNA 6%
• Anti-Bacterial Agents 5%

Chemical Compounds

• Bleomycin 40%
• Cleavage 30%
• Bleomycin A5 9%
• Linear DNA Duplexes 8%
• Antineoplastic Antibiotic 6%
• Oxidative Elimination Reaction 5%
• Thiazole 5%
• Binding Agent 4%
• Antimicrobial Agent 3%
• Metal Ion 3%

Engineering & Materials Science

• DNA 45%
• RNA 8%
• Metal ions 5%
• Antibiotics 5%
• Substrates 5%
• Metals 4%
• Binders 3%
• Resins 3%