Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults

Jinni Su; Sally I.Chun Kuo; Fazil Aliev; Jill A. Rabinowitz; Belal Jamil; Grace Chan; Howard J. Edenberg; Meredith Francis; Victor Hesselbrock; Chella Kamarajan; Sivan Kinreich; John Kramer; Donbing Lai; Vivia McCutcheon; Jacquelyn Meyers; Ashwini Pandey; Gayathri Pandey; Martin H. Plawecki; Marc Schuckit; Jay Tischfield; Danielle M. Dick

doi:10.1017/S0954579423001141

Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults

Jinni Su, Sally I.Chun Kuo, Fazil Aliev, Jill A. Rabinowitz, Belal Jamil, Grace Chan, Howard J. Edenberg, Meredith Francis, Victor Hesselbrock, Chella Kamarajan, Sivan Kinreich, John Kramer, Donbing Lai, Vivia McCutcheon, Jacquelyn Meyers, Ashwini Pandey, Gayathri Pandey, Martin H. Plawecki, Marc Schuckit, Jay TischfieldDanielle M. Dick

Research output: Contribution to journal › Article › peer-review

Abstract

Alcohol use is influenced by genetic and environmental factors. We examined the interactive effects between genome-wide polygenic risk scores for alcohol use (alc-PRS) and social support in relation to alcohol use among European American (EA) and African American (AA) adults across sex and developmental stages (emerging adulthood, young adulthood, and middle adulthood). Data were drawn from 4,011 EA and 1,274 AA adults from the Collaborative Study on the Genetics of Alcoholism who were between ages 18-65 and had ever used alcohol. Participants completed the Semi-Structured Assessment for the Genetics of Alcoholism and provided saliva or blood samples for genotyping. Results indicated that social support from friends, but not family, moderated the association between alc-PRS and alcohol use among EAs and AAs (only in middle adulthood for AAs); alc-PRS was associated with higher levels of alcohol use when friend support was low, but not when friend support was high. Associations were similar across sex but differed across developmental stages. Findings support the important role of social support from friends in buffering genetic risk for alcohol use among EA and AA adults and highlight the need to consider developmental changes in the role of social support in relation to alcohol use.

Original language	English (US)
Journal	Development and psychopathology
DOIs	https://doi.org/10.1017/S0954579423001141
State	Accepted/In press - 2023
Externally published	Yes

Keywords

COGA
alcohol use
gene-environment interaction
polygenic scores
social support

ASJC Scopus subject areas

Developmental and Educational Psychology
Psychiatry and Mental health

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10.1017/S0954579423001141

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Su, J., Kuo, S. I. C., Aliev, F., Rabinowitz, J. A., Jamil, B., Chan, G., Edenberg, H. J., Francis, M., Hesselbrock, V., Kamarajan, C., Kinreich, S., Kramer, J., Lai, D., McCutcheon, V., Meyers, J., Pandey, A., Pandey, G., Plawecki, M. H., Schuckit, M., ... Dick, D. M. (Accepted/In press). Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults. Development and psychopathology. https://doi.org/10.1017/S0954579423001141

Su, J, Kuo, SIC, Aliev, F, Rabinowitz, JA, Jamil, B, Chan, G, Edenberg, HJ, Francis, M, Hesselbrock, V, Kamarajan, C, Kinreich, S, Kramer, J, Lai, D, McCutcheon, V, Meyers, J, Pandey, A, Pandey, G, Plawecki, MH, Schuckit, M, Tischfield, J & Dick, DM 2023, 'Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults', Development and psychopathology. https://doi.org/10.1017/S0954579423001141

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title = "Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults",

abstract = "Alcohol use is influenced by genetic and environmental factors. We examined the interactive effects between genome-wide polygenic risk scores for alcohol use (alc-PRS) and social support in relation to alcohol use among European American (EA) and African American (AA) adults across sex and developmental stages (emerging adulthood, young adulthood, and middle adulthood). Data were drawn from 4,011 EA and 1,274 AA adults from the Collaborative Study on the Genetics of Alcoholism who were between ages 18-65 and had ever used alcohol. Participants completed the Semi-Structured Assessment for the Genetics of Alcoholism and provided saliva or blood samples for genotyping. Results indicated that social support from friends, but not family, moderated the association between alc-PRS and alcohol use among EAs and AAs (only in middle adulthood for AAs); alc-PRS was associated with higher levels of alcohol use when friend support was low, but not when friend support was high. Associations were similar across sex but differed across developmental stages. Findings support the important role of social support from friends in buffering genetic risk for alcohol use among EA and AA adults and highlight the need to consider developmental changes in the role of social support in relation to alcohol use.",

keywords = "COGA, alcohol use, gene-environment interaction, polygenic scores, social support",

author = "Jinni Su and Kuo, {Sally I.Chun} and Fazil Aliev and Rabinowitz, {Jill A.} and Belal Jamil and Grace Chan and Edenberg, {Howard J.} and Meredith Francis and Victor Hesselbrock and Chella Kamarajan and Sivan Kinreich and John Kramer and Donbing Lai and Vivia McCutcheon and Jacquelyn Meyers and Ashwini Pandey and Gayathri Pandey and Plawecki, {Martin H.} and Marc Schuckit and Jay Tischfield and Dick, {Danielle M.}",

note = "Publisher Copyright: {\textcopyright} The Author(s), 2023. Published by Cambridge University Press.",

year = "2023",

doi = "10.1017/S0954579423001141",

language = "English (US)",

journal = "Development and psychopathology",

issn = "0954-5794",

publisher = "Cambridge University Press",

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TY - JOUR

T1 - Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults

AU - Su, Jinni

AU - Kuo, Sally I.Chun

AU - Aliev, Fazil

AU - Rabinowitz, Jill A.

AU - Jamil, Belal

AU - Chan, Grace

AU - Edenberg, Howard J.

AU - Francis, Meredith

AU - Hesselbrock, Victor

AU - Kamarajan, Chella

AU - Kinreich, Sivan

AU - Kramer, John

AU - Lai, Donbing

AU - McCutcheon, Vivia

AU - Meyers, Jacquelyn

AU - Pandey, Ashwini

AU - Pandey, Gayathri

AU - Plawecki, Martin H.

AU - Schuckit, Marc

AU - Tischfield, Jay

AU - Dick, Danielle M.

PY - 2023

Y1 - 2023

N2 - Alcohol use is influenced by genetic and environmental factors. We examined the interactive effects between genome-wide polygenic risk scores for alcohol use (alc-PRS) and social support in relation to alcohol use among European American (EA) and African American (AA) adults across sex and developmental stages (emerging adulthood, young adulthood, and middle adulthood). Data were drawn from 4,011 EA and 1,274 AA adults from the Collaborative Study on the Genetics of Alcoholism who were between ages 18-65 and had ever used alcohol. Participants completed the Semi-Structured Assessment for the Genetics of Alcoholism and provided saliva or blood samples for genotyping. Results indicated that social support from friends, but not family, moderated the association between alc-PRS and alcohol use among EAs and AAs (only in middle adulthood for AAs); alc-PRS was associated with higher levels of alcohol use when friend support was low, but not when friend support was high. Associations were similar across sex but differed across developmental stages. Findings support the important role of social support from friends in buffering genetic risk for alcohol use among EA and AA adults and highlight the need to consider developmental changes in the role of social support in relation to alcohol use.

AB - Alcohol use is influenced by genetic and environmental factors. We examined the interactive effects between genome-wide polygenic risk scores for alcohol use (alc-PRS) and social support in relation to alcohol use among European American (EA) and African American (AA) adults across sex and developmental stages (emerging adulthood, young adulthood, and middle adulthood). Data were drawn from 4,011 EA and 1,274 AA adults from the Collaborative Study on the Genetics of Alcoholism who were between ages 18-65 and had ever used alcohol. Participants completed the Semi-Structured Assessment for the Genetics of Alcoholism and provided saliva or blood samples for genotyping. Results indicated that social support from friends, but not family, moderated the association between alc-PRS and alcohol use among EAs and AAs (only in middle adulthood for AAs); alc-PRS was associated with higher levels of alcohol use when friend support was low, but not when friend support was high. Associations were similar across sex but differed across developmental stages. Findings support the important role of social support from friends in buffering genetic risk for alcohol use among EA and AA adults and highlight the need to consider developmental changes in the role of social support in relation to alcohol use.

KW - COGA

KW - alcohol use

KW - gene-environment interaction

KW - polygenic scores

KW - social support

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JO - Development and psychopathology

JF - Development and psychopathology

ER -

Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults

Abstract

Keywords

ASJC Scopus subject areas

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