Agents, Modeling Processes, and the Allure of Prophecy

William Griffin, Manfred D. Laubichler, Werner Callebaut

Research output: Contribution to journalArticlepeer-review


Ioannidis [Why most published research findings are false. PLoS Med 2(8): e124 (2005)] identifies six factors that contribute to explaining why most of the current published research findings are more likely to be false than true, and argues that for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias. In this article, we argue that three “hot” areas in current biological research, viz., agent-based modeling, evolutionary developmental biology (EvoDevo), and systems biology, are especially prone to the flaws.

Original languageEnglish (US)
Pages (from-to)73-78
Number of pages6
JournalBiological Theory
Issue number1
StatePublished - Mar 2008


  • agent-based models (ABMs)
  • bias
  • EvoDevo
  • quality of research
  • research findings
  • systems biology

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • History and Philosophy of Science


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