@article{0b36fe35c5824ee68244b598c88e0885,
title = "Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems",
abstract = "Studies on pattern formation in coculture cell systems can provide insights into many physiological and pathological processes. Here, we investigate how the extracellular matrix (ECM) may influence the patterning in coculture systems. The model coculture system we use is composed of highly motile invasive breast cancer cells, initially mixed with inert nonmetastatic cells on a 2D substrate and covered with a Matrigel layer introduced to mimic ECM. We observe that the invasive cells exhibit persistent centripetal motion and yield abnormal aggregation, rather than random spreading, due to a {"}collective pulling{"} effect resulting from ECM-mediated transmission of active contractile forces generated by the polarized migration of the invasive cells along the vertical direction. The mechanism we report may open a new window for the understanding of biological processes that involve multiple types of cells.",
author = "Xiaochen Wang and Shaohua Chen and Hanqing Nan and Ruchuan Liu and Yu Ding and Kena Song and Jianwei Shuai and Qihui Fan and Yu Zheng and Fangfu Ye and Yang Jiao and Liyu Liu",
note = "Funding Information: The authors would like to thank the engineer of Soft Matter Lab Yongliang Zhai for the design and fabrication on a homemade live-cell incubating system. This work was supported by the National Natural Science Foundation of China (Grant Nos. 11774394, 11974066, 12074407, and 12090054), the Strategic Priority Research Program of Chinese Academy of Sciences (Grant No. XDB33000000), the Start-Up Fund and University Graduate Fellowship of Arizona State University, the Natural Science Foundation of Chongqing Municipal Science and Technology Commission (Grant No. cstc2019jcyj-msxmX0477), the Fundamental Research Funds for the Central Universities (Grant No. 2019CDY-GYB007), and the Capital Health Development Research Project, China (Grant No. 2020-2-2072). Publisher Copyright: {\textcopyright} 2022 Territorios. All rights reserved.",
year = "2021",
doi = "10.34133/2021/9893131",
language = "English (US)",
volume = "2021",
journal = "Research",
issn = "2096-5168",
publisher = "American Association for the Advancement of Science",
}