TY - CHAP
T1 - AAV2-neurturin for Parkinson’s disease
T2 - What lessons have we learned?
AU - Kordower, Jeffrey H.
N1 - Publisher Copyright:
© Springer Science+Business Media New York 2016.
PY - 2016
Y1 - 2016
N2 - The dream that trophic factors could be effectively delivered and potently forestall and reverse the symptoms of Parkinson’s disease (PD) has yet to be realized. Research in this area has been active for 20 years, but after much work, the prospects for utilizing trophic factors in the treatment of PD are currently dim. Millions of dollars have been spent, numerous academic, foundation, and government resources have been invested, and hundreds of patient research volunteers have contributed their time and hope to this effort without a therapeutic breakthrough. As a scientist who has journeyed these events from the beginning and participated in many of the decisions that navigated this field, I consider it important for the movement disorder scientific community to reflect on the evolution of thought and to participate in the dialog over whether the investments were worthwhile. The most studied group of trophic factor for PD is the glial cell derived family of ligands, of which glial cell derived neurotrophic factor (GDNF) and neurturin are members, and are the best studied. I trace the development of these factors chronologically with commentary on the key decision-making points. Before we collectively invest further, I offer this scientific reflection on the past and offer my own view on the next steps of research in the field of neurotrophins as potential therapeutic agents in PD.
AB - The dream that trophic factors could be effectively delivered and potently forestall and reverse the symptoms of Parkinson’s disease (PD) has yet to be realized. Research in this area has been active for 20 years, but after much work, the prospects for utilizing trophic factors in the treatment of PD are currently dim. Millions of dollars have been spent, numerous academic, foundation, and government resources have been invested, and hundreds of patient research volunteers have contributed their time and hope to this effort without a therapeutic breakthrough. As a scientist who has journeyed these events from the beginning and participated in many of the decisions that navigated this field, I consider it important for the movement disorder scientific community to reflect on the evolution of thought and to participate in the dialog over whether the investments were worthwhile. The most studied group of trophic factor for PD is the glial cell derived family of ligands, of which glial cell derived neurotrophic factor (GDNF) and neurturin are members, and are the best studied. I trace the development of these factors chronologically with commentary on the key decision-making points. Before we collectively invest further, I offer this scientific reflection on the past and offer my own view on the next steps of research in the field of neurotrophins as potential therapeutic agents in PD.
KW - AAV
KW - Clinical trial
KW - GDNF
KW - Neurturin
KW - Nigrostriatal system
KW - Parkinson’s disease
UR - http://www.scopus.com/inward/record.url?scp=84948467134&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84948467134&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-3271-9_32
DO - 10.1007/978-1-4939-3271-9_32
M3 - Chapter
C2 - 26611606
AN - SCOPUS:84948467134
T3 - Methods in Molecular Biology
SP - 485
EP - 490
BT - Methods in Molecular Biology
PB - Humana Press Inc.
ER -