A user friendly system for ultrasound carotid intima-media thickness image interpretation

Xiangjun Zhu, Christopher B. Kendall, R. Todd Hurst, Jianming Liang

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    3 Scopus citations


    Assessment of Carotid Intima-Media Thickness (CIMT) by B-mode ultrasound is a technically mature and reproducible technology. Given the high morbidity, mortality and the large societal burden associated with CV diseases, as a safe yet inexpensive tool, CIMT is increasingly utilized for cardiovascular (CV) risk stratification. However, CIMT requires a precise measure of the thickness of the intima and media layers of the carotid artery that can be tedious, time consuming, and demand specialized expertise and experience. To this end, we have developed a highly user-friendly system for semiautomatic CIMT image interpretation. Our contribution is the application of active contour models (snake models) with hard constraints, leading to an accurate, adaptive and user-friendly border detection algorithm. A comparison study with the CIMT measurement software in Siemens Syngo® Arterial Health Package shows that our system gives a small bias in mean (0.049 ±0.051mm) and maximum (0.010 ± 0.083 mm) CIMT measures and offers a higher reproducibility (average correlation coefficients were 0.948 and 0.844 in mean and maximum CIMT respectively (P <0.001)). This superior performance is attributed to our novel interface design for hard constraints in the snake models.

    Original languageEnglish (US)
    Title of host publicationMedical Imaging 2011
    Subtitle of host publicationUltrasonic Imaging, Tomography, and Therapy
    StatePublished - Jun 8 2011
    EventMedical Imaging 2011: Ultrasonic Imaging, Tomography, and Therapy - Lake Buena Vista, FL, United States
    Duration: Feb 13 2011Feb 14 2011

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    ISSN (Print)1605-7422


    OtherMedical Imaging 2011: Ultrasonic Imaging, Tomography, and Therapy
    Country/TerritoryUnited States
    CityLake Buena Vista, FL


    • User-Friendly Software Systems
    • active contour models
    • cardiovascular disease
    • snakes with hard constraints
    • ultrasound Carotid Intima-Media Thickness (CIMT)

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging


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