A system and method to interface with multiple groups of axons in several fascicles of peripheral nerves

Anil K. Thota, Sathyakumar Kuntaegowdanahalli, Amy K. Starosciak, James Abbas, Jorge Orbay, Kenneth W. Horch, Ranu Jung

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Background: Several neural interface technologies that stimulate and/or record from groups of axons have been developed. The longitudinal intrafascicular electrode (LIFE) is a fine wire that can provide access to a discrete population of axons within a peripheral nerve fascicle. Some applications require, or would benefit greatly from, technology that could provide access to multiple discrete sites in several fascicles. New method: The distributed intrafascicular multi-electrode (DIME) lead was developed to deploy multiple LIFEs to several fascicles. It consists of several (e.g. six) LIFEs that are coiled and placed in a sheath for strength and durability, with a portion left uncoiled to allow insertion at distinct sites. We have also developed a multi-lead multi-electrode (MLME) management system that includes a set of sheaths and procedures for fabrication and deployment. Results: A prototype with 3 DIME leads was fabricated and tested in a procedure in a cadaver arm. The leads were successfully routed through skin and connective tissue and the deployment procedures were utilized to insert the LIFEs into fascicles of two nerves. Comparison with existing method(s): Most multi-electrode systems use a single-lead, multi-electrode design. For some applications, this design may be limited by the bulk of the multi-contact array and/or by the spatial distribution of the electrodes. Conclusion: We have designed a system that can be used to access multiple sets of discrete groups of fibers that are spatially distributed in one or more fascicles of peripheral nerves. This system may be useful for neural-enabled prostheses or other applications.

Original languageEnglish (US)
Pages (from-to)78-84
Number of pages7
JournalJournal of Neuroscience Methods
StatePublished - Apr 5 2015


  • Intrafascicular electrode
  • Multi-electrode
  • Neuroprosthesis
  • Peripheral nerve interface

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'A system and method to interface with multiple groups of axons in several fascicles of peripheral nerves'. Together they form a unique fingerprint.

Cite this