A simple method to make a membrane with regions of differential permeability

Ying Horng Steve Liu, Eric A. Livesay, Kevin J. Luebke, Stephen Albert Johnston

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


We describe a method of using heat to produce any pattern of differential permeability in commercially available fluid permeable membranes. An aluminum heating block is machined with specific patterns, heated, and placed in contact with a continuous sheet of polypropylene membrane in order to create impermeable regions in the otherwise permeable membrane. The permeability of the membrane to fluid can be altered by this method in any pattern chosen. Such differentially permeable membranes can be used in high-density, multi-well filtration plates for chemical syntheses or biological assays.

Original languageEnglish (US)
Pages (from-to)95-101
Number of pages7
JournalJournal of Membrane Science
Issue number1-2
StatePublished - Apr 15 2003
Externally publishedYes


  • Biotechnology
  • High-density filter plate
  • Liquid permeability and separations
  • Microfiltration
  • Microporous and porous membranes

ASJC Scopus subject areas

  • Biochemistry
  • Materials Science(all)
  • Physical and Theoretical Chemistry
  • Filtration and Separation


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