A radical-relay approach to biocatalytic C–N bond formation

Jackson J. Tennant; Kyle F. Biegasiewicz

doi:10.1016/j.checat.2022.09.034

A radical-relay approach to biocatalytic C–N bond formation

Jackson J. Tennant, Kyle F. Biegasiewicz

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Abstract

The mechanistic reprogramming of enzymes to perform new chemical reactions has emerged as a powerful strategy for addressing long-standing challenges in organic synthesis. In a recent Science article, Huang and co-workers report on the discovery and development of an abiological radical-relay C(sp³)–H azidation catalyzed by nonheme iron enzymes.

Original language	English (US)
Pages (from-to)	2446-2448
Number of pages	3
Journal	Chem Catalysis
Volume	2
Issue number	10
DOIs	https://doi.org/10.1016/j.checat.2022.09.034
State	Published - Oct 20 2022

ASJC Scopus subject areas

Chemistry (miscellaneous)
Physical and Theoretical Chemistry
Organic Chemistry

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10.1016/j.checat.2022.09.034

Cite this

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title = "A radical-relay approach to biocatalytic C–N bond formation",

abstract = "The mechanistic reprogramming of enzymes to perform new chemical reactions has emerged as a powerful strategy for addressing long-standing challenges in organic synthesis. In a recent Science article, Huang and co-workers report on the discovery and development of an abiological radical-relay C(sp3)–H azidation catalyzed by nonheme iron enzymes.",

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AB - The mechanistic reprogramming of enzymes to perform new chemical reactions has emerged as a powerful strategy for addressing long-standing challenges in organic synthesis. In a recent Science article, Huang and co-workers report on the discovery and development of an abiological radical-relay C(sp3)–H azidation catalyzed by nonheme iron enzymes.

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A radical-relay approach to biocatalytic C–N bond formation

Abstract

ASJC Scopus subject areas

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