A new strategy for the synthesis of bisaminoacylated tRNAs

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Tandemly activated tRNAs participate effectively in protein synthesis and exhibit superior chemical and biochemical stability compared to the more commonly used singly aminoacylated tRNAs. While several bisaminoacylated tRNAs have been prepared via the T4 RNA ligase-mediated condensation of bisaminoacylated pdCpAs and abbreviated tRNA transcripts (tRNA-C OH), the bisaminoacylated pdCpAs are difficult to prepare when using bulky amino acids. Described herein is a new strategy for preparing bisaminoacylated tRNAs, applicable even for bulky amino acids.

Original languageEnglish (US)
Pages (from-to)4906-4909
Number of pages4
JournalOrganic Letters
Issue number18
StatePublished - Sep 16 2011

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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