A new approach towards predictability of epileptic seizures: KLT dimension

Rajeshkumar Venugopal, Narayanan Krishnamurthi, Awadhesh Prasad, Andreas Spanias, J. C. Sackellares, L. D. Iasemidis

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


This paper proposes a measure of complexity of the epileptic electroencephalogram (EEG) based on the dimensionality of the Karhunen-Loeve Transform (KLT) in the time domain. We estimate the KLT dimensionality by assuming the same observation noise level in the EEG during the interictal period (between the seizures) as the one during an epileptic seizure (ictal period). Utilizing an optimality criterion based on the T-index [1] and the predictability time, derived from the created KLT dimensionality profiles, we show that 10 out of 15 seizures in one patient with temporal lobe epilepsy were predictable with an average predictability time of about 36 minutes.

Original languageEnglish (US)
Pages (from-to)123-128
Number of pages6
JournalBiomedical Sciences Instrumentation
StatePublished - 2003


  • Biomedical signal processing
  • Electroencephalogram
  • KLT
  • Lyapunov exponents
  • Seizure prediction
  • T-index
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Biophysics
  • Medical Laboratory Technology


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