A Microsatellite-Based Multipoint Index Map of Human Chromosome 22

Kenneth H. Buetow, David Duggan, Bosheng Yang, Susan Ludwigsen, Jennifer Puck, Joanne Porter, Marcia Budarf, Richard Spielman, Beverly S. Emanuel

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Utilizing the CEPH (Centre d’Etude du Polymorphisme Humain) reference panel and genotyping data for 24 simple tandem repeat polymorphism (STRP) markers, we have constructed a 15-locus multipoint genetic framework map of human chromosome 22. The markers form a continuous linkage group of 51 cM in males and 81 cM in females. Likely genetic locations are provided for 9 additional STRP sequences. The map was constructed employing the CRIMAP computational methodology to build the multipoint map via a stepwise algorithm. The quality of the framework map was evaluated using a battery of statistical diagnostics that suggest a typing error frequency of 0.1% for markers within the map.

Original languageEnglish (US)
Pages (from-to)329-339
Number of pages11
Issue number2
StatePublished - Nov 1993
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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