A microflow amperometric glucose biosensor

Bruce C. Towe, Vincent Pizziconi

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


We investigate a small glucose sensor that uses a flow-through enzyme bed and reaction endpoint approach that seems particularly suited to microdialysis-type subcutaneous or intravascular glucose sensors. The particular configuration has the advantage of relative insensitivity to blood oxygen changes and also to factors which affect enzyme activity compared to conventional polarographic type glucose sensors. We evaluate the placement of a microdialysis fiber into a near-surface blood vessel in the dog model as a mean of blood glucose sampling and to determine the effects of protein deposition. We observe a progressive decline in intravascular membrane fiber transport that must be considered in sensor design.

Original languageEnglish (US)
Pages (from-to)893-899
Number of pages7
JournalBiosensors and Bioelectronics
Issue number9-10
StatePublished - Nov 1 1997


  • Amperometric glucose sensor
  • Glucose sensor
  • Microdialysis
  • Microflow sensor

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry


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