A longitudinal study of neuropsychological change in individuals with Parkinson's disease

Tamiko Azuma, Robyn F. Cruz, Kathryn A. Bayles, Cheryl K. Tomoeda, E. B. Montgomery

    Research output: Contribution to journalArticlepeer-review

    50 Scopus citations


    Objectives: Neuropsychological changes in individuals with Parkinson's disease (PD) were studied longitudinally. Methods: Sixty-nine idiopathic PD patients, with Mini-Mental State Examination (MMSE) scores falling within normal range, and 37 elderly control participants were given neuropsychological tests twice approximately two years apart. Results: The PD group performed poorer than the control group on Semantic Fluency, Letter Fluency, Modified Wisconsin Card Sorting Task, and Block Design at test time 1. Two years later, the PD group snowed significant decline in Semantic and Letter Fluency. A subset of 12 PD patients declined in mental status by second testing (>4 MMSE points). Cox proportional-hazards models were used to see if any baseline measures were associated with relative risk of decline in mental status. In the final model, Repetition performance and Age were significantly associated with cognitive decline. Conclusions: Consistent with previous studies, executive function tasks were those most susceptible to disease progression.

    Original languageEnglish (US)
    Pages (from-to)1115-1120
    Number of pages6
    JournalInternational Journal of Geriatric Psychiatry
    Issue number12
    StatePublished - Dec 2003


    • Cognitive change
    • Longitudinal study
    • Parkinson's disease

    ASJC Scopus subject areas

    • Geriatrics and Gerontology
    • Psychiatry and Mental health


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