A facile one-step in situ functionalization of quantum dots with preserved photoluminescence for bioconjugation

Qiangbin Wang; Yang Xu; Xiaohang Zhao; Yung Chang; Yan Liu; Lijing Jiang; Jaswinder Sharma; Dong Seo; Hao Yan

doi:10.1021/ja071434y

A facile one-step in situ functionalization of quantum dots with preserved photoluminescence for bioconjugation

Qiangbin Wang, Yang Xu, Xiaohang Zhao, Yung Chang, Yan Liu, Lijing Jiang, Jaswinder Sharma, Dong Seo, Hao Yan

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

Herein we report a new and simple method of in situ functionalization of CdSe QDs and surface passivation by a thin ZnS shell at the same time. This method avoids a second-step ligand exchange after the core-shell formation and preserved high quantum yield of the QDs. We demonstrated that such prepared QDs can serve as excellent nanomaterial for bioconjugation. Different antibodies were conjugated to the MPA-functionalized QDs and resulted in highly stable and highly photoluminescent nanoparticles for cell labeling purposes.

Original language	English (US)
Pages (from-to)	6380-6381
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	129
Issue number	20
DOIs	https://doi.org/10.1021/ja071434y
State	Published - May 23 2007

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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abstract = "Herein we report a new and simple method of in situ functionalization of CdSe QDs and surface passivation by a thin ZnS shell at the same time. This method avoids a second-step ligand exchange after the core-shell formation and preserved high quantum yield of the QDs. We demonstrated that such prepared QDs can serve as excellent nanomaterial for bioconjugation. Different antibodies were conjugated to the MPA-functionalized QDs and resulted in highly stable and highly photoluminescent nanoparticles for cell labeling purposes.",

author = "Qiangbin Wang and Yang Xu and Xiaohang Zhao and Yung Chang and Yan Liu and Lijing Jiang and Jaswinder Sharma and Dong Seo and Hao Yan",

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T1 - A facile one-step in situ functionalization of quantum dots with preserved photoluminescence for bioconjugation

AU - Wang, Qiangbin

AU - Xu, Yang

AU - Zhao, Xiaohang

AU - Chang, Yung

AU - Liu, Yan

AU - Jiang, Lijing

AU - Sharma, Jaswinder

AU - Seo, Dong

AU - Yan, Hao

PY - 2007/5/23

Y1 - 2007/5/23

N2 - Herein we report a new and simple method of in situ functionalization of CdSe QDs and surface passivation by a thin ZnS shell at the same time. This method avoids a second-step ligand exchange after the core-shell formation and preserved high quantum yield of the QDs. We demonstrated that such prepared QDs can serve as excellent nanomaterial for bioconjugation. Different antibodies were conjugated to the MPA-functionalized QDs and resulted in highly stable and highly photoluminescent nanoparticles for cell labeling purposes.

AB - Herein we report a new and simple method of in situ functionalization of CdSe QDs and surface passivation by a thin ZnS shell at the same time. This method avoids a second-step ligand exchange after the core-shell formation and preserved high quantum yield of the QDs. We demonstrated that such prepared QDs can serve as excellent nanomaterial for bioconjugation. Different antibodies were conjugated to the MPA-functionalized QDs and resulted in highly stable and highly photoluminescent nanoparticles for cell labeling purposes.

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SP - 6380

EP - 6381

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 20

ER -

A facile one-step in situ functionalization of quantum dots with preserved photoluminescence for bioconjugation

Abstract

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