A facile in situ generation of dithiocarbamate ligands for stable gold nanoparticle-oligonucleotide conjugates

Jaswinder Sharma; Rahul Chhabra; Hao Yan; Yan Liu

doi:10.1039/b800109j

A facile in situ generation of dithiocarbamate ligands for stable gold nanoparticle-oligonucleotide conjugates

Jaswinder Sharma, Rahul Chhabra, Hao Yan, Yan Liu

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Here we demonstrate a facile strategy of preparing gold nanoparticle (AuNP) and DNA conjugates by in situ generation of strong metal affinity capping ligands, dithiocarbamates (DTC) modified oligonucleotides; the conjugates produced are stable at elevated temperature, resistant to ligand displacement and preserve the functionality of the conjugated oligonucleotides.

Original language	English (US)
Pages (from-to)	2140-2142
Number of pages	3
Journal	Chemical Communications
Issue number	18
DOIs	https://doi.org/10.1039/b800109j
State	Published - 2008

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b800109j

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title = "A facile in situ generation of dithiocarbamate ligands for stable gold nanoparticle-oligonucleotide conjugates",

abstract = "Here we demonstrate a facile strategy of preparing gold nanoparticle (AuNP) and DNA conjugates by in situ generation of strong metal affinity capping ligands, dithiocarbamates (DTC) modified oligonucleotides; the conjugates produced are stable at elevated temperature, resistant to ligand displacement and preserve the functionality of the conjugated oligonucleotides.",

author = "Jaswinder Sharma and Rahul Chhabra and Hao Yan and Yan Liu",

year = "2008",

doi = "10.1039/b800109j",

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journal = "Chemical Communications",

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T1 - A facile in situ generation of dithiocarbamate ligands for stable gold nanoparticle-oligonucleotide conjugates

AU - Sharma, Jaswinder

AU - Chhabra, Rahul

AU - Yan, Hao

AU - Liu, Yan

PY - 2008

Y1 - 2008

N2 - Here we demonstrate a facile strategy of preparing gold nanoparticle (AuNP) and DNA conjugates by in situ generation of strong metal affinity capping ligands, dithiocarbamates (DTC) modified oligonucleotides; the conjugates produced are stable at elevated temperature, resistant to ligand displacement and preserve the functionality of the conjugated oligonucleotides.

AB - Here we demonstrate a facile strategy of preparing gold nanoparticle (AuNP) and DNA conjugates by in situ generation of strong metal affinity capping ligands, dithiocarbamates (DTC) modified oligonucleotides; the conjugates produced are stable at elevated temperature, resistant to ligand displacement and preserve the functionality of the conjugated oligonucleotides.

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DO - 10.1039/b800109j

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JO - Chemical Communications

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ER -

A facile in situ generation of dithiocarbamate ligands for stable gold nanoparticle-oligonucleotide conjugates

Abstract

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