A Deep Learning Approach for Targeted Contrast-Enhanced Ultrasound Based Prostate Cancer Detection

Yujie Feng, Fan Yang, Xichuan Zhou, Yanli Guo, Fang Tang, Fengbo Ren, Jishun Guo, Shuiwang Ji

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


The important role of angiogenesis in cancer development has driven many researchers to investigate the prospects of noninvasive cancer diagnosis based on the technology of contrast-enhanced ultrasound (CEUS) imaging. This paper presents a deep learning framework to detect prostate cancer in the sequential CEUS images. The proposed method uniformly extracts features from both the spatial and the temporal dimensions by performing three-dimensional convolution operations, which captures the dynamic information of the perfusion process encoded in multiple adjacent frames for prostate cancer detection. The deep learning models were trained and validated against expert delineations over the CEUS images recorded using two types of contrast agents, i.e., the anti-PSMA based agent targeted to prostate cancer cells and the non-targeted blank agent. Experiments showed that the deep learning method achieved over 91 percent specificity and 90 percent average accuracy over the targeted CEUS images for prostate cancer detection, which was superior ($p<0.05$p<0.05) than previously reported approaches and implementations.

Original languageEnglish (US)
Article number8357938
Pages (from-to)1794-1801
Number of pages8
JournalIEEE/ACM Transactions on Computational Biology and Bioinformatics
Issue number6
StatePublished - Nov 1 2019


  • Contrast-enhanced ultrasound
  • convolutional neural network
  • prostate cancer detection
  • targeted agent

ASJC Scopus subject areas

  • Biotechnology
  • Genetics
  • Applied Mathematics


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