@article{3fb970a2cd014b90b4ea20faa9ffd323,
title = "A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation",
abstract = "The orthopoxvirus vaccinia virus sensitizes cells to TNF-induced necroptosis, but it is not known whether other orthopoxviruses also sensitize cells to necroptosis. Liu et al. demonstrate that a family of orthopoxvirus viral inhibitors target RIPK3 for proteasomal degradation. This strategy critically controls viral replication and antiviral innate immunity.",
keywords = "F-box, RIPK3, TNF, ankyrin repeats, cowpox virus, inflammation, necroptosis, poxvirus, ubiquitination, vaccinia virus",
author = "Zhijun Liu and Himani Nailwal and Jonah Rector and Rahman, {Masmudur M.} and Richard Sam and Grant McFadden and Chan, {Francis Ka Ming}",
note = "Funding Information: We thank members of the Chan lab for discussion. This work was supported by National Institute of Allergy and Infectious Diseases (United States) grants AI 128197 , AI148302 (F.C.), and R01 AI080607 (G.M.). We thank the Duke University School of Medicine for the use of the Microbiome Core Facility for help with NanoString data acquisition. Funding Information: We thank members of the Chan lab for discussion. This work was supported by National Institute of Allergy and Infectious Diseases (United States) grants AI 128197, AI148302 (F.C.), and R01 AI080607 (G.M.). We thank the Duke University School of Medicine for the use of the Microbiome Core Facility for help with NanoString data acquisition. Conceptualization, F.K.-M.C. and G.M.; Methodology, F.K.-M.C. and G.M.; Investigation, Z.L. H.N. J.R. R.S. and F.K.-M.C.; Writing ? Original Draft, F.K.-M.C.; Writing ? Review & Editing, Z.L. G.M. M.M.R. and F.K.-M.C.; Funding Acquisition, F.K.-M.C. and G.M.; Resources, G.M. and M.M.R.; Supervision, F.K.-M.C. A U.S. provisional patent application (no. 62/848,255) has been filed for this study. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2021",
month = feb,
day = "9",
doi = "10.1016/j.immuni.2020.11.020",
language = "English (US)",
volume = "54",
pages = "247--258.e7",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "2",
}