TY - JOUR
T1 - A bird’s-eye view of the endoplasmic reticulum in filamentous fungi
AU - Martínez-Andrade, Juan M.
AU - Roberson, Robert W.
AU - Riquelme, Meritxell
N1 - Publisher Copyright:
© 2024 American Society for Microbiology. All rights reserved.
PY - 2024/3
Y1 - 2024/3
N2 - The endoplasmic reticulum (ER) is one of the most extensive organelles in eukaryotic cells. It performs crucial roles in protein and lipid synthesis and Ca2+ homeostasis. Most information on ER types, functions, organization, and domains comes from studies in uninucleate animal, plant, and yeast cells. In contrast, there is limited information on the multinucleate cells of filamentous fungi, i.e., hyphae. We provide an analytical review of existing literature to categorize different types of ER described in filamentous fungi while emphasizing the research techniques and markers used. Additionally, we identify the knowledge gaps that need to be resolved better to understand the structure-function correlation of ER in filamentous fungi. Finally, advanced technologies that can provide breakthroughs in understanding the ER in filamentous fungi are discussed.
AB - The endoplasmic reticulum (ER) is one of the most extensive organelles in eukaryotic cells. It performs crucial roles in protein and lipid synthesis and Ca2+ homeostasis. Most information on ER types, functions, organization, and domains comes from studies in uninucleate animal, plant, and yeast cells. In contrast, there is limited information on the multinucleate cells of filamentous fungi, i.e., hyphae. We provide an analytical review of existing literature to categorize different types of ER described in filamentous fungi while emphasizing the research techniques and markers used. Additionally, we identify the knowledge gaps that need to be resolved better to understand the structure-function correlation of ER in filamentous fungi. Finally, advanced technologies that can provide breakthroughs in understanding the ER in filamentous fungi are discussed.
KW - endoplasmic reticulum
KW - filamentous fungi
KW - fluorescence microscopy
KW - secretory pathway
KW - transmission electron microscopy
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U2 - 10.1128/mmbr.00027-23
DO - 10.1128/mmbr.00027-23
M3 - Review article
C2 - 38372526
AN - SCOPUS:85188915876
SN - 1092-2172
VL - 88
JO - Microbiology and Molecular Biology Reviews
JF - Microbiology and Molecular Biology Reviews
IS - 1
ER -