ASU-Banner Neurodegenerative Disease Research Center (NDRC)

Projects

Projects per year 2015 2016 2018 2019 2021 2022 2027

• 24 Active
• 52 Finished

Projects per year

Search results

• Active

  Using Peripheral Microglial Exosomes to predict brain inflammation in the human Parkinsons brain

  Kordower, J. & Mastroeni, D.

  HHS: National Institutes of Health (NIH)

  9/18/23 → 8/31/25

  Project: Research project

  • Exosomes 100%
  • Encephalitis 90%
  • Microglia 86%
  • Extracellular Vesicles 62%
  • Brain 41%

• Unraveling new signaling pathway for tau-mediated neurodegeneration

  Tseng, J.

  Alzheimer's Association

  8/16/23 → 4/30/25

  Project: Research project

• Tau protein proteolysis signaling in Alzheimer's disease

  Huseby, C.

  HHS: National Institutes of Health (NIH)

  8/15/23 → 7/31/25

  Project: Research project

  • tau Proteins 100%
  • Proteolysis 74%
  • Alzheimer Disease 61%
  • Peptides 50%
  • Peptide Hydrolases 22%

• Molecular Tool Development to Identify, Isolate, and Interrogate the Rod Microglia Phenotype in Neurological Disease and Injury

  Stabenfeldt, S. & Mastroeni, D.

  HHS: National Institutes of Health (NIH)

  8/1/23 → 12/31/27

  Project: Research project

  • Microglia 100%
  • Phenotype 59%
  • Wounds and Injuries 47%
  • Traumatic Brain Injury 9%
  • Antibodies 8%

• Contributions of Hindbrain Pathology to Alzheimer's Disease

  Mastroeni, D.

  Alzheimer's Association

  11/1/22 → 10/31/24

  Project: Research project

  • Raphe Nuclei 100%
  • Rhombencephalon 94%
  • Alzheimer Disease 58%
  • Pathology 47%
  • Relaxin 28%

• Commercialization of selective Dyrk1a inhibitors for Down syndrome

  Velazquez, R.

  HHS: National Institutes of Health (NIH)

  10/1/22 → 8/31/24

  Project: Research project

  • Down syndrome 100%
  • commercialization 74%
  • mice 39%
  • mouth 15%
  • chromosomes 12%

• PET Imaging of alpha synuclein

  Kordower, J.

  INDUSTRY: Domestic Company

  8/11/22 → 8/10/24

  Project: Research project

  • positron-emission tomography 100%
  • injection 43%
  • Primates 37%
  • brain 36%
  • immunohistochemistry 31%

• tau NHP models

  Kordower, J.

  INDUSTRY: Domestic Company

  8/5/22 → 8/4/24

  Project: Research project

  • animal models 100%
  • immunohistochemistry 96%
  • brain 79%
  • young adults 62%
  • staining 56%

• Phase 1b trial of dopaminergic stem cells in parkin patients

  Kordower, J.

  Michael J. Fox Foundation

  1/11/22 → 1/11/25

  Project: Research project

  • 1,2-diarachidonoyl-glycero-3-phosphocholine 100%
  • Dopamine 64%
  • Stem Cells 55%
  • Parkinson Disease 50%
  • Transplants 28%

• Bifunctional intrabody targeting intracellular alpha-synuclein

  Kordower, J.

  Michael J. Fox Foundation

  1/1/22 → 2/1/25

  Project: Research project

  • alpha-Synuclein 100%
  • Single-Domain Antibodies 87%
  • Organoids 70%
  • Synucleins 29%
  • Organized Financing 23%

• Seelos Therapeutics SRA

  Kordower, J.

  INDUSTRY: Domestic Company

  11/1/21 → 10/31/24

  Project: Research project

  • confidential information 100%
  • industry research 97%
  • reasonable effort 58%
  • obligation 57%
  • contract price 56%

• Kinase activation in multiple system atrophy

  Kordower, J.

  HHS: National Institutes of Health (NIH)

  10/1/21 → 8/31/24

  Project: Research project

  • Activation 100%
  • Confidentiality 17%
  • Performance 16%
  • Obligation 16%
  • Person 13%

• Co-Pathologies Drive Neuroinflammation and Progression in PD

  Kordower, J.

  Michael J. Fox Foundation

  10/1/21 → 9/30/24

  Project: Research project

  • Pathology 100%
  • Major Histocompatibility Complex 73%
  • Inflammation 46%
  • T-Lymphocytes 44%
  • Microglia 36%

• Differential diagnosis of Parkinson's and multiple system atrophy in non-human primate models using a novel a-synuclein retinal contrast agent and AI-assisted analytics

  Kordower, J.

  HHS: National Institutes of Health (NIH)

  9/23/21 → 8/31/24

  Project: Research project

  • Synucleins 100%
  • Multiple System Atrophy 87%
  • Primates 61%
  • Contrast Media 60%
  • Differential Diagnosis 51%

• Arizona Alzheimer's Disease Research Center (ADRC)

  Bimonte-Nelson, H., Readhead, B. & Coon, D.

  HHS: National Institutes of Health (NIH)

  9/5/21 → 6/30/26

  Project: Research project

  • dementia 100%
  • blood samples 28%
  • performance 18%
  • brain 16%
  • director 16%

• Tau based Monkey model of Alzheimer's Disease; Structure and Function

  Kordower, J.

  HHS: National Institutes of Health (NIH)

  9/1/21 → 5/31/25

  Project: Research project

  • Alzheimer's Disease 100%
  • Monkey 90%
  • Data Collection 54%
  • Surgery 40%
  • Manuscripts 30%

• Reprogramming astrocytes to functional dopaminergic neurons in non-human primate brain

  Kordower, J.

  Michael J. Fox Foundation

  7/1/21 → 8/31/24

  Project: Research project

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 100%
  • Primates 73%
  • Haplorhini 72%
  • Astrocytes 72%
  • Brain 38%

• Monkeypox virus, Interferon, and Necroptosis

  Jacobs, B. & Kibler, K.

  HHS: National Institutes of Health (NIH)

  8/18/20 → 7/31/25

  Project: Research project

  • Monkeypox virus 100%
  • Necroptosis 83%
  • Interferons 54%
  • Immune Evasion 32%
  • Vaccinia virus 23%

• Modulation of Alzheimers disease by Herpes simplex virus infection

  Readhead, B.

  HHS: National Institutes of Health (NIH)

  9/1/19 → 5/31/24

  Project: Research project

  • Herpes Simplex 100%
  • Alzheimer Disease 66%
  • Forensic Anthropology 37%
  • Biological Phenomena 27%
  • Consensus 27%

• S6K1 as a novel link between aging and Alzheimers disease

  Readhead, B. & Velazquez, R.

  HHS: National Institutes of Health (NIH)

  4/15/19 → 2/28/25

  Project: Research project

  • Ribosomal Protein S6 Kinases 100%
  • Alzheimer Disease 55%
  • Alzheimer disease type 1 16%
  • Retinoblastoma-Binding Protein 7 14%
  • Astrocytes 6%

• Novel in Situ Proteomics Methods to Classify Cell Types in Alzheimers Brains

  Guo, J. & Coleman, P.

  HHS: National Institutes of Health (NIH)

  9/20/18 → 6/30/24

  Project: Research project

  • Proteomics 100%
  • Formaldehyde 58%
  • Paraffin 58%
  • Brain 53%
  • single cell proteins 53%

• Identify common mechanisms of neurodegeneration between Alzheimers disease and Down syndrome

  Velazquez, R.

  HHS: National Institutes of Health (NIH)

  9/15/18 → 5/31/24

  Project: Research project

  • Down Syndrome 100%
  • Alzheimer Disease 74%

• Identification of the genetic and transcriptomic networks of cognitive and neurop

  Readhead, B.

  HHS: National Institutes of Health (NIH)

  9/1/18 → 4/30/25

  Project: Research project

  • Alzheimer Disease 100%
  • Satellite Viruses 29%
  • Herpesviridae 21%
  • Organoids 20%
  • Proteomics 14%

• Workforce inclusion in neuroscience through undergraduate research experience

  Velazquez, R.

  HHS: National Institutes of Health (NIH)

  7/1/18 → 6/30/24

  Project: Research project

  • neurosciences 100%
  • inclusion 69%
  • experience 31%