Biodesign: CES Mass Spectrometry Facility

Equipment/facility: Facility

  • Location

    United States

Equipments Details


The Center for Environmental Security Mass Spectrometry Facility provides MS analysis to ASU research groups requiring analysis of proteins, peptides and small molecules. Researchers are encouraged to discuss their projects and sample preparation protocols with the facility manager for optimum results.

Matrix Assisted Laser Desorption Ionization (MALDI) is a soft ionization technique for mass spectrometry allowing for measuring a variety of large biomolecules and organic molecules. With the OptiBeam™ on-axis laser setup, ten times greater sensitivity is achieved for identifying and quantifying low-abundance samples in complex biological samples. Ideal for carbohydrates, lipids, biopolymers and other large organic compounds.

The AB SCIEX API 4000™ LC/MS/MS system uses the TurboIonSpray® probe and the atmospheric pressure chemical ionization (APCI) probe to produce ions from liquid samples. The term LC/MS/MS, applied to the triple quadrupole series, is a generic label for the combined analytical processes of liquid separation and subsequent mass spectrometric analysis. The instrument is configured to perform complex MS/MS analysis, but it can, for less rigorous analytical requirements, perform single MS (LC/MS) scans. The API 4000 LC/MS/MS system allows all modes of MS/MS operation for full characterization of biopharmaceutical compounds and the specificity needed for new drug development. For pharmaceutical and pharmakinetic samples, MS/MS has the sensitivity and specificity required to analyze hundreds of samples per day without extensive sample preparation.

The Agilent GS-MS Triple Quad instrument is a state-of-the art gas chromatograph that provides superior performance for all applications. Key to its performance is the use of advanced electronic pneumatic control (EPC) modules and high performance GC oven temperature control.

Finnigan LTQ
Thermo Electron Finnigan LTQ (linear trap quadrupole) is an ion-trap based mass spectrometer. The instrument offers high resolution and sensitivity in mass analysis, which includes sub ppm mass accuracy. Thanks to this high mass resolving power and accuracy, the instrument is well suited for characterizing single compounds in complex mixtures. High sensitivity helps define structural characteristics for traditionally tough applications with complex compounds. In addition to providing superior analytical power, the hardware of the instrument (particularly the ion source) supports high sample throughput. With this advanced level of efficiency, analytical bottlenecks created by high throughput synthesis and screening are relieved, benefiting the overall laboratory productivity.

Contact: Eileen Yue


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