Worldwide population structure, long-term demography, and local adaptation of Helicobacter pylori

Valeria Montano, Xavier Didelot, Matthieu Foll, Bodo Linz, Richard Reinhardt, Sebastian Suerbaum, Yoshan Moodley, Jeffrey D. Jensen

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Helicobacter pylori is an important human pathogen associated with serious gastric diseases. Owing to its medical importance and close relationship with its human host, understanding genomic patterns of global and local adaptation in H. pylori may be of particular significance for both clinical and evolutionary studies. Here we present the first such whole genome analysis of 60 globally distributed strains, from which we inferred worldwide population structure and demographic history and shed light on interesting global and local events of positive selection, with particular emphasis on the evolution of San-associated lineages. Our results indicate a more ancient origin for the association of humans and H. pylori than previously thought. We identify several important perspectives for future clinical research on candidate selected regions that include both previously characterized genes (e.g., transcription elongation factor NusA and tumor necrosis factor alpha-inducing protein Tipα) and hitherto unknown functional genes.

Original languageEnglish (US)
Pages (from-to)947-963
Number of pages17
Issue number3
StatePublished - Jul 1 2015
Externally publishedYes


  • Adaptation
  • Human pathogens
  • Neutral evolution

ASJC Scopus subject areas

  • Genetics


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