Wearable Transcutaneous CO Monitor Based on Miniaturized Nondispersive Infrared Sensor

Vishal Varun Tipparaju, Sabrina Jimena Mora, Jingjing Yu, Francis Tsow, Xiaojun Xian

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Transcutaneous oxygen and carbon dioxide provide the status of pulmonary gas exchange and are of importance in diagnosis and management of respiratory diseases. Though significant progress has been made in oximetry, not much has been explored in developing wearable technologies for continuous monitoring of transcutaneous carbon dioxide. This research reports the development of a truly wearable sensor for continuous monitoring of transcutaneous carbon dioxide using miniaturized nondispersive infrared sensor augmented by hydrophobic membrane to address the humidity interference. The wearable transcutaneous CO2 monitor shows well-behaved response curve to humid CO2 with linear response to CO2 concentration. The profile of transcutaneous CO2 monitored by the wearable device correlates well with the end-tidal CO2 trend in human test. The feasibility of the wearable device for passive and unobstructed tracking of transcutaneous CO2 in free-living conditions has also been demonstrated in field test. The wearable transcutaneous CO2 monitoring technology developed in this research can be widely used in remote assessment of pulmonary gas exchange efficiency for patients with respiratory diseases, such as COVID-19, sleep apnea, and chronic obstructive pulmonary disease (COPD).

Original languageEnglish (US)
Article number9435386
Pages (from-to)17327-17334
Number of pages8
JournalIEEE Sensors Journal
Issue number15
StatePublished - Aug 1 2021


  • Arterial blood gases
  • end-tidal CO2
  • nondispersive infrared (NDIR) sensor
  • respiratory diseases
  • transcutaneous CO2
  • wearable
  • wristband

ASJC Scopus subject areas

  • Instrumentation
  • Electrical and Electronic Engineering


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