Prejudice and hate directed toward Asian individuals has increased in prevalence and salience during the COVID-19 pandemic, with notable rises in physical violence. Concurrently, as many governments enacted stay-at-home mandates, the spread of anti-Asian content increased in online spaces, including social media. In the present study, we investigated temporal and geographical patterns in social media content relevant to anti-Asian prejudice during the COVID-19 pandemic. Using the Twitter Data Collection API, we queried over 13 million tweets posted between January 30, 2020, and April 30, 2021, for both negative (e.g., #kungflu) and positive (e.g., #stopAAPIhate) hashtags and keywords related to anti-Asian prejudice. In a series of descriptive analyses, we found differences in the frequency of negative and positive keywords based on geographic location. Using burst detection, we also identified distinct increases in negative and positive content in relation to key political tweets and events. These largely exploratory analyses shed light on the role of social media in the expression and proliferation of prejudice as well as positive responses online.