Virus-encoded receptors for cytokines and chemokines

G. McFadden, A. Lalani, H. Everett, P. Nash, X. Xu

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


A number of viruses, particularly members of the poxvirus, herpesvirus and retrovirus families, have adapted to the vertebrate immune responses by capturing and modifying cellular genes which regulate the host immune system. Included among these host-derived virus genes are modified versions of receptors for cytokines or chemokines. Most of these receptor homologs, also called viroceptors, are either secreted glycoproteins or are located at the infected cell surface. Although these viroceptors can act in different ways, collectively they function by modifying the cytokine network to the advantage of the virus rather than the host.

Original languageEnglish (US)
Pages (from-to)359-368
Number of pages10
JournalSeminars in Cell and Developmental Biology
Issue number3
StatePublished - Jun 1998
Externally publishedYes


  • Chemokines
  • Interferon
  • Interleukin-1
  • Tumor necrosis factor
  • Viroceptors
  • Virokines

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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