Viral proteins and the mitochondrial apoptotic checkpoint

Helen Everett, Grant McFadden

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Regulated cell death by apoptosis constitutes a primary host defense for counteracting invading viral pathogens. In recent years, advances in the field of apoptosis research have revealed that mitochondria and mitochondria-derived factors play a central role in regulating cellular commitment to apoptosis. Here we explore the role of viral proteins in modulating cell death pathways that are relayed via this mitochondrial checkpoint.

Original languageEnglish (US)
Pages (from-to)181-188
Number of pages8
JournalCytokine and Growth Factor Reviews
Issue number2-3
StatePublished - 2001
Externally publishedYes


  • Apoptosis
  • Mitochondria
  • Permeability transition
  • Virus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)


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