Viral proteins and the mitochondrial apoptotic checkpoint

Helen Everett; Grant McFadden

doi:10.1016/S1359-6101(00)00025-3

Viral proteins and the mitochondrial apoptotic checkpoint

Helen Everett, Grant McFadden

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Regulated cell death by apoptosis constitutes a primary host defense for counteracting invading viral pathogens. In recent years, advances in the field of apoptosis research have revealed that mitochondria and mitochondria-derived factors play a central role in regulating cellular commitment to apoptosis. Here we explore the role of viral proteins in modulating cell death pathways that are relayed via this mitochondrial checkpoint.

Original language	English (US)
Pages (from-to)	181-188
Number of pages	8
Journal	Cytokine and Growth Factor Reviews
Volume	12
Issue number	2-3
DOIs	https://doi.org/10.1016/S1359-6101(00)00025-3
State	Published - 2001
Externally published	Yes

Keywords

Apoptosis
Mitochondria
Permeability transition
Virus

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology
Biochemistry, Genetics and Molecular Biology(all)

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10.1016/S1359-6101(00)00025-3

Cite this

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title = "Viral proteins and the mitochondrial apoptotic checkpoint",

abstract = "Regulated cell death by apoptosis constitutes a primary host defense for counteracting invading viral pathogens. In recent years, advances in the field of apoptosis research have revealed that mitochondria and mitochondria-derived factors play a central role in regulating cellular commitment to apoptosis. Here we explore the role of viral proteins in modulating cell death pathways that are relayed via this mitochondrial checkpoint.",

keywords = "Apoptosis, Mitochondria, Permeability transition, Virus",

author = "Helen Everett and Grant McFadden",

note = "Funding Information: The authors wish to thank Dr X. Sun (Department of Oncology, University of Alberta) for assistance with compiling the movie. The authors' work is supported by the Medical Research Council and the National Cancer Institute of Canada. G.M. is a Medical Research Council Senior Scientist and H.E. is a recipient of a University of Alberta Dissertation Fellowship. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

year = "2001",

doi = "10.1016/S1359-6101(00)00025-3",

language = "English (US)",

volume = "12",

pages = "181--188",

journal = "Cytokine and Growth Factor Reviews",

issn = "1359-6101",

publisher = "Elsevier BV",

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}

TY - JOUR

T1 - Viral proteins and the mitochondrial apoptotic checkpoint

AU - Everett, Helen

AU - McFadden, Grant

N1 - Funding Information: The authors wish to thank Dr X. Sun (Department of Oncology, University of Alberta) for assistance with compiling the movie. The authors' work is supported by the Medical Research Council and the National Cancer Institute of Canada. G.M. is a Medical Research Council Senior Scientist and H.E. is a recipient of a University of Alberta Dissertation Fellowship. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 2001

Y1 - 2001

N2 - Regulated cell death by apoptosis constitutes a primary host defense for counteracting invading viral pathogens. In recent years, advances in the field of apoptosis research have revealed that mitochondria and mitochondria-derived factors play a central role in regulating cellular commitment to apoptosis. Here we explore the role of viral proteins in modulating cell death pathways that are relayed via this mitochondrial checkpoint.

AB - Regulated cell death by apoptosis constitutes a primary host defense for counteracting invading viral pathogens. In recent years, advances in the field of apoptosis research have revealed that mitochondria and mitochondria-derived factors play a central role in regulating cellular commitment to apoptosis. Here we explore the role of viral proteins in modulating cell death pathways that are relayed via this mitochondrial checkpoint.

KW - Apoptosis

KW - Mitochondria

KW - Permeability transition

KW - Virus

UR - http://www.scopus.com/inward/record.url?scp=0034959818&partnerID=8YFLogxK

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U2 - 10.1016/S1359-6101(00)00025-3

DO - 10.1016/S1359-6101(00)00025-3

M3 - Review article

C2 - 11325601

AN - SCOPUS:0034959818

SN - 1359-6101

VL - 12

SP - 181

EP - 188

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

IS - 2-3

ER -

Viral proteins and the mitochondrial apoptotic checkpoint

Abstract

Keywords

ASJC Scopus subject areas

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