Urinary catecholamines and mitral valve prolapse in panic-anxiety patients

Randolph M. Nesse, Oliver G. Cameron, Andrew J. Buda, Daisy S. McCann, George C. Curtis, Marla J. Huber-Smith

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Free norepinephrine and epinephrine were measured in two consecutive 12-hour urine collections gathered during normal activity and sleep from 23 panic-anxiety patients and 9 normal subjects. Mitral value prolapse (MVP) was found in 7 of 20 patients who had echocardiograms. Mean nighttime norepinephrine and epinephrine excretion in panic-anxiety patients without MVP was significantly higher than that of control subjects, and was significantly higher than that of anxiety patients with MVP. In the daytime, all groups had higher catecholamine (CA) levels, but the differences between the groups were less pronounced. Medication significantly relieved symptoms and was associated with decreased CA levels. Elevated basal CA levels may characterize the subgroup of panic-anxiety patients who do not have MVP.

Original languageEnglish (US)
Pages (from-to)67-75
Number of pages9
JournalPsychiatry Research
Issue number1
StatePublished - Jan 1985
Externally publishedYes


  • Panic
  • anxiety
  • epinephrine
  • humans
  • mitral valve prolapse
  • norepinephrine
  • urine

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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