Urinary catecholamines and mitral valve prolapse in panic-anxiety patients

Randolph M. Nesse; Oliver G. Cameron; Andrew J. Buda; Daisy S. McCann; George C. Curtis; Marla J. Huber-Smith

doi:10.1016/0165-1781(85)90090-3

Urinary catecholamines and mitral valve prolapse in panic-anxiety patients

Randolph M. Nesse, Oliver G. Cameron, Andrew J. Buda, Daisy S. McCann, George C. Curtis, Marla J. Huber-Smith

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Free norepinephrine and epinephrine were measured in two consecutive 12-hour urine collections gathered during normal activity and sleep from 23 panic-anxiety patients and 9 normal subjects. Mitral value prolapse (MVP) was found in 7 of 20 patients who had echocardiograms. Mean nighttime norepinephrine and epinephrine excretion in panic-anxiety patients without MVP was significantly higher than that of control subjects, and was significantly higher than that of anxiety patients with MVP. In the daytime, all groups had higher catecholamine (CA) levels, but the differences between the groups were less pronounced. Medication significantly relieved symptoms and was associated with decreased CA levels. Elevated basal CA levels may characterize the subgroup of panic-anxiety patients who do not have MVP.

Original language	English (US)
Pages (from-to)	67-75
Number of pages	9
Journal	Psychiatry Research
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(85)90090-3
State	Published - Jan 1985
Externally published	Yes

Keywords

Panic
anxiety
epinephrine
humans
mitral valve prolapse
norepinephrine
urine

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0165-1781(85)90090-3

Cite this

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title = "Urinary catecholamines and mitral valve prolapse in panic-anxiety patients",

abstract = "Free norepinephrine and epinephrine were measured in two consecutive 12-hour urine collections gathered during normal activity and sleep from 23 panic-anxiety patients and 9 normal subjects. Mitral value prolapse (MVP) was found in 7 of 20 patients who had echocardiograms. Mean nighttime norepinephrine and epinephrine excretion in panic-anxiety patients without MVP was significantly higher than that of control subjects, and was significantly higher than that of anxiety patients with MVP. In the daytime, all groups had higher catecholamine (CA) levels, but the differences between the groups were less pronounced. Medication significantly relieved symptoms and was associated with decreased CA levels. Elevated basal CA levels may characterize the subgroup of panic-anxiety patients who do not have MVP.",

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AU - Nesse, Randolph M.

AU - Cameron, Oliver G.

AU - Buda, Andrew J.

AU - McCann, Daisy S.

AU - Curtis, George C.

AU - Huber-Smith, Marla J.

PY - 1985/1

Y1 - 1985/1

N2 - Free norepinephrine and epinephrine were measured in two consecutive 12-hour urine collections gathered during normal activity and sleep from 23 panic-anxiety patients and 9 normal subjects. Mitral value prolapse (MVP) was found in 7 of 20 patients who had echocardiograms. Mean nighttime norepinephrine and epinephrine excretion in panic-anxiety patients without MVP was significantly higher than that of control subjects, and was significantly higher than that of anxiety patients with MVP. In the daytime, all groups had higher catecholamine (CA) levels, but the differences between the groups were less pronounced. Medication significantly relieved symptoms and was associated with decreased CA levels. Elevated basal CA levels may characterize the subgroup of panic-anxiety patients who do not have MVP.

AB - Free norepinephrine and epinephrine were measured in two consecutive 12-hour urine collections gathered during normal activity and sleep from 23 panic-anxiety patients and 9 normal subjects. Mitral value prolapse (MVP) was found in 7 of 20 patients who had echocardiograms. Mean nighttime norepinephrine and epinephrine excretion in panic-anxiety patients without MVP was significantly higher than that of control subjects, and was significantly higher than that of anxiety patients with MVP. In the daytime, all groups had higher catecholamine (CA) levels, but the differences between the groups were less pronounced. Medication significantly relieved symptoms and was associated with decreased CA levels. Elevated basal CA levels may characterize the subgroup of panic-anxiety patients who do not have MVP.

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KW - anxiety

KW - epinephrine

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KW - mitral valve prolapse

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KW - urine

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Urinary catecholamines and mitral valve prolapse in panic-anxiety patients

Abstract

Keywords

ASJC Scopus subject areas

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