Untreated type 2 diabetes and its complications are associated with subcortical infarctions

Rosebud O. Roberts; Kejal Kantarci; Yonas E. Geda; David S. Knopman; Scott A. Przybelski; Stephen D. Weigand; Ronald C. Petersen; Clifford R. Jack

doi:10.2337/dc10-0602

Untreated type 2 diabetes and its complications are associated with subcortical infarctions

Rosebud O. Roberts, Kejal Kantarci, Yonas E. Geda, David S. Knopman, Scott A. Przybelski, Stephen D. Weigand, Ronald C. Petersen, Clifford R. Jack

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

OBJECTIVE - To investigate the association of type 2 diabetes with subcortical infarctions. RESEARCH DESIGN AND METHODS - We investigated this association in subjects with type 2 diabetes (case subjects; n = 93) and without type 2 diabetes (control subjects; n = 186), matched by age, sex, and years of education. Participants were a subset of the Mayo Clinic Study of Aging (median age 79 years) who had undergone magnetic resonance imaging. RESULTS - The frequency of subcortical infarctions was 39% in case subjects and 29% in control subjects (odds ratio 1.59 [95% CI 0.91-2.75]). The association was stronger in case subjects without treatment (2.60 [1.11- 6.08]) and in case subjects with diabetes-related complications (1.96 [1.02-3.74]) compared with control subjects. CONCLUSIONS - These findings suggest that untreated type 2 diabetes and type 2 diabetes with complications are associated with subcortical infarctions.

Original language	English (US)
Pages (from-to)	184-186
Number of pages	3
Journal	Diabetes Care
Volume	34
Issue number	1
DOIs	https://doi.org/10.2337/dc10-0602
State	Published - Jan 2011
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Advanced and Specialized Nursing

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title = "Untreated type 2 diabetes and its complications are associated with subcortical infarctions",

abstract = "OBJECTIVE - To investigate the association of type 2 diabetes with subcortical infarctions. RESEARCH DESIGN AND METHODS - We investigated this association in subjects with type 2 diabetes (case subjects; n = 93) and without type 2 diabetes (control subjects; n = 186), matched by age, sex, and years of education. Participants were a subset of the Mayo Clinic Study of Aging (median age 79 years) who had undergone magnetic resonance imaging. RESULTS - The frequency of subcortical infarctions was 39% in case subjects and 29% in control subjects (odds ratio 1.59 [95% CI 0.91-2.75]). The association was stronger in case subjects without treatment (2.60 [1.11- 6.08]) and in case subjects with diabetes-related complications (1.96 [1.02-3.74]) compared with control subjects. CONCLUSIONS - These findings suggest that untreated type 2 diabetes and type 2 diabetes with complications are associated with subcortical infarctions.",

author = "Roberts, {Rosebud O.} and Kejal Kantarci and Geda, {Yonas E.} and Knopman, {David S.} and Przybelski, {Scott A.} and Weigand, {Stephen D.} and Petersen, {Ronald C.} and Jack, {Clifford R.}",

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doi = "10.2337/dc10-0602",

language = "English (US)",

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T1 - Untreated type 2 diabetes and its complications are associated with subcortical infarctions

AU - Roberts, Rosebud O.

AU - Kantarci, Kejal

AU - Geda, Yonas E.

AU - Knopman, David S.

AU - Przybelski, Scott A.

AU - Weigand, Stephen D.

AU - Petersen, Ronald C.

AU - Jack, Clifford R.

PY - 2011/1

Y1 - 2011/1

N2 - OBJECTIVE - To investigate the association of type 2 diabetes with subcortical infarctions. RESEARCH DESIGN AND METHODS - We investigated this association in subjects with type 2 diabetes (case subjects; n = 93) and without type 2 diabetes (control subjects; n = 186), matched by age, sex, and years of education. Participants were a subset of the Mayo Clinic Study of Aging (median age 79 years) who had undergone magnetic resonance imaging. RESULTS - The frequency of subcortical infarctions was 39% in case subjects and 29% in control subjects (odds ratio 1.59 [95% CI 0.91-2.75]). The association was stronger in case subjects without treatment (2.60 [1.11- 6.08]) and in case subjects with diabetes-related complications (1.96 [1.02-3.74]) compared with control subjects. CONCLUSIONS - These findings suggest that untreated type 2 diabetes and type 2 diabetes with complications are associated with subcortical infarctions.

AB - OBJECTIVE - To investigate the association of type 2 diabetes with subcortical infarctions. RESEARCH DESIGN AND METHODS - We investigated this association in subjects with type 2 diabetes (case subjects; n = 93) and without type 2 diabetes (control subjects; n = 186), matched by age, sex, and years of education. Participants were a subset of the Mayo Clinic Study of Aging (median age 79 years) who had undergone magnetic resonance imaging. RESULTS - The frequency of subcortical infarctions was 39% in case subjects and 29% in control subjects (odds ratio 1.59 [95% CI 0.91-2.75]). The association was stronger in case subjects without treatment (2.60 [1.11- 6.08]) and in case subjects with diabetes-related complications (1.96 [1.02-3.74]) compared with control subjects. CONCLUSIONS - These findings suggest that untreated type 2 diabetes and type 2 diabetes with complications are associated with subcortical infarctions.

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JO - Diabetes Care

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Untreated type 2 diabetes and its complications are associated with subcortical infarctions

Abstract

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