Unmet clinical need in autoimmune liver diseases

Jessica K. Dyson; Gwilym Webb; Gideon M. Hirschfield; Ansgar Lohse; Ulrich Beuers; Keith Lindor; David E J Jones

doi:10.1016/j.jhep.2014.09.010

Unmet clinical need in autoimmune liver diseases

Jessica K. Dyson
, Gwilym Webb
, Gideon M. Hirschfield
, Ansgar Lohse
, Ulrich Beuers
, Keith Lindor
, David E J Jones

Research output: Contribution to journal › Review article › peer-review

63 Scopus citations

Abstract

Summary Despite recent advances in understanding and treatment, there remain significant areas of unmet clinical need in each of the autoimmune liver diseases (AILDs). The evolving research landscape and emerging large patient cohorts are creating unique opportunities to translate science into new therapies and care pathways, with the potential to significantly improve the lives of AILD patients. However, the areas of unmet need represent real challenges, which need to be addressed, if this vision is to be realised. This review describes the areas of unmet need in AILD in adults relating to diagnostic and prognostic assessment, primary therapy, symptom management, trial design and delivery, and structured care delivery, with the aim of focusing future research prioritisation.

Original language	English (US)
Pages (from-to)	208-218
Number of pages	11
Journal	Journal of Hepatology
Volume	62
Issue number	1
DOIs	https://doi.org/10.1016/j.jhep.2014.09.010
State	Published - Jan 1 2015

Keywords

Autoimmune hepatitis
Autoimmune liver diseases
IgG4 disease
Primary biliary cirrhosis
Primary sclerosing cholangitis
Stratified care delivery
Unmet clinical need

ASJC Scopus subject areas

Hepatology

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10.1016/j.jhep.2014.09.010

Cite this

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title = "Unmet clinical need in autoimmune liver diseases",

abstract = "Summary Despite recent advances in understanding and treatment, there remain significant areas of unmet clinical need in each of the autoimmune liver diseases (AILDs). The evolving research landscape and emerging large patient cohorts are creating unique opportunities to translate science into new therapies and care pathways, with the potential to significantly improve the lives of AILD patients. However, the areas of unmet need represent real challenges, which need to be addressed, if this vision is to be realised. This review describes the areas of unmet need in AILD in adults relating to diagnostic and prognostic assessment, primary therapy, symptom management, trial design and delivery, and structured care delivery, with the aim of focusing future research prioritisation.",

keywords = "Autoimmune hepatitis, Autoimmune liver diseases, IgG4 disease, Primary biliary cirrhosis, Primary sclerosing cholangitis, Stratified care delivery, Unmet clinical need",

author = "Dyson, \{Jessica K.\} and Gwilym Webb and Hirschfield, \{Gideon M.\} and Ansgar Lohse and Ulrich Beuers and Keith Lindor and Jones, \{David E J\}",

note = "Funding Information: The UK-PBC Research Consortium is funded by the Medical Research Council and works with, and receives funding from, industrial partners working in the area of therapy in PBC, including Intercept and Lumena. ",

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doi = "10.1016/j.jhep.2014.09.010",

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AU - Dyson, Jessica K.

AU - Webb, Gwilym

AU - Hirschfield, Gideon M.

AU - Lohse, Ansgar

AU - Beuers, Ulrich

AU - Lindor, Keith

AU - Jones, David E J

N1 - Funding Information: The UK-PBC Research Consortium is funded by the Medical Research Council and works with, and receives funding from, industrial partners working in the area of therapy in PBC, including Intercept and Lumena.

PY - 2015/1/1

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N2 - Summary Despite recent advances in understanding and treatment, there remain significant areas of unmet clinical need in each of the autoimmune liver diseases (AILDs). The evolving research landscape and emerging large patient cohorts are creating unique opportunities to translate science into new therapies and care pathways, with the potential to significantly improve the lives of AILD patients. However, the areas of unmet need represent real challenges, which need to be addressed, if this vision is to be realised. This review describes the areas of unmet need in AILD in adults relating to diagnostic and prognostic assessment, primary therapy, symptom management, trial design and delivery, and structured care delivery, with the aim of focusing future research prioritisation.

AB - Summary Despite recent advances in understanding and treatment, there remain significant areas of unmet clinical need in each of the autoimmune liver diseases (AILDs). The evolving research landscape and emerging large patient cohorts are creating unique opportunities to translate science into new therapies and care pathways, with the potential to significantly improve the lives of AILD patients. However, the areas of unmet need represent real challenges, which need to be addressed, if this vision is to be realised. This review describes the areas of unmet need in AILD in adults relating to diagnostic and prognostic assessment, primary therapy, symptom management, trial design and delivery, and structured care delivery, with the aim of focusing future research prioritisation.

KW - Autoimmune hepatitis

KW - Autoimmune liver diseases

KW - IgG4 disease

KW - Primary biliary cirrhosis

KW - Primary sclerosing cholangitis

KW - Stratified care delivery

KW - Unmet clinical need

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M3 - Review article

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Unmet clinical need in autoimmune liver diseases

Abstract

Keywords

ASJC Scopus subject areas

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