Ultrasonic cardiac pacing in the porcine model

Bruce C. Towe, Raymond Rho

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Periodic pulses of intense ultrasound energy at 70 kHz with 5-ms duration at 3 MPa SPL applied to the exposed pig myocardium at physiologic rhythms were observed to produce cardiac pacing. Ten animals were successfully paced at pulse width and energy conditions above a certain threshold. Sigmoid strength-duration curves characterizing ultrasound's effectiveness in pacing were observed to resemble those of electrical stimulation. We suggest that bioelectrical stimulatory effects of ultrasound on the heart are a radiation pressure effect and a manifestation of the known myocyte sensitivity to stretch.

Original languageEnglish (US)
Article number1643417
Pages (from-to)1446-1448
Number of pages3
JournalIEEE Transactions on Biomedical Engineering
Issue number7
StatePublished - Jul 2006


  • Radiation pressure stimulation
  • Ultrasonic pacing
  • Ultrasound bioelectric stimulation

ASJC Scopus subject areas

  • Biomedical Engineering


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